Nūhou - He hana maoli anei ka Licorice Extract Glabridin?

I. Hoolauna

Ua hoʻomaikaʻi ka ʻoihana mālama ʻili i ka maikaʻi keʻokeʻo o "ʻO Glabridin"(Wehe ʻia mai Glycyrrhiza glabra) ʻoiai ʻoi aku ia ma mua o ke alakaʻi keʻokeʻo arbutin e 1164 mau manawa, loaʻa ke poʻo inoa o "ke gula keʻokeʻo"!

I ka hoʻololi ʻana o nā kau a hoʻonani ʻia nā alanui me nā "wāwae ʻole a me nā lima ʻole," ʻo ke kumuhana o ke kamaʻilio ʻana ma waena o ka poʻe hoihoi nani, ma waho aʻe o ka pale ʻana i ka lā, ʻaʻole hiki ke huli i ka ʻili keʻokeʻo.

Ma ke aupuni o ka mālama ʻana i ka ʻili, nui ka nui o nā mea keʻokeʻo, me ka vitamina C, niacinamide, arbutin, hydroquinone, kojic acid, tranexamic acid, glutathione, ferulic acid, phenethylresorcinol (377), a me nā mea hou aku. Eia naʻe, ʻo ka mea hoʻohui "glabridin" ua hoʻopiʻi i ka hoihoi o nā mea pā, e koi ana i kahi ʻimi hohonu e wehe i kona ulu kaulana. E ʻimi kākou i nā kikoʻī!

Ma o kēia ʻatikala, manaʻo mākou e kamaʻilio i kēia mau mea nui:
(1) He aha ke kumu o Glabridin? Pehea e pili ai i "Glycyrrhiza glabra extract"?
(2) No ke aha i mahalo ʻia ai ʻo "Glabridin" he "gula keʻokeʻo"?
(3) He aha nā pōmaikaʻi o "Glabridin"?
(4) Pehea e hoʻokō ai ʻo Glabridin i kāna mau hopena keʻokeʻo?
(5) He ikaika maoli anei ka licorice e like me ka olelo?
(6) He aha nā huahana mālama ʻili i loaʻa iā Glabridin?

No.1 Ke wehe nei i ke kumu o "Glabridin"

ʻO Glabridin, he lālā o ka ʻohana flavonoids licorice, loaʻa mai ka mea kanu "Glycyrrhiza glabra." Ma koʻu ʻāina, ʻewalu mau ʻano nui o ka licorice, me ʻekolu mau ʻano i hoʻokomo ʻia i loko o ka "Pharmacopoeia," ʻo ia ka Ural licorice, licorice bulge, a me ka licorice glabra. Loaʻa wale ʻia ʻo Glycyrrhizin ma Glycyrrhiza glabra, e lawelawe ana ma ke ʻano he isoflavone mua o ka mea kanu.

ʻO ke ʻano o ka glycyrrhizin
ʻIke mua ʻia e ka hui Kepani ʻo MARUZEN a lawe ʻia mai Glycyrrhiza glabra, hoʻohana nui ʻia ʻo glycyrrhizin ma ke ʻano he mea hoʻohui i nā huahana mālama ʻili keʻokeʻo ma Iapana, Korea, a me nā hōʻailona mālama ʻili honua. Eia naʻe, he mea nui e hoʻomaopopo i ka mea i helu ʻia i loko o nā huahana mālama ʻili a mākou e hoʻohana ai ʻaʻole paha he "glycyrrhizin" akā ʻo "Glycyrrhiza extract." ʻOiai ʻo "Glycyrrhizin" he mea hoʻokahi, hiki i ka "Glycyrrhiza extract" ke hoʻopili i nā ʻāpana ʻē aʻe ʻaʻole i hoʻokaʻawale ʻia a hoʻomaʻemaʻe ʻia, hiki ke lawelawe ʻia ma ke ʻano he ʻoihana kūʻai aku e hoʻoikaika i nā ʻano "kūlohelohe" o ka huahana.

No.2 No ke aha i kapa ʻia ai ka licorice "Gold Whitener"?

ʻO Glycyrrhizin kahi mea paʻakikī a paʻakikī e unuhi. ʻAʻole maʻalahi ka loaʻa ʻana o Glycyrrhiza glabra i ka nui. Hoʻohui pū ʻia me nā paʻakikī o ke kaʻina o ka unuhi ʻana, hiki ke loaʻa ma lalo o 100 grams mai ka 1 ton o nā kumu licorice hou a me nā lau. ʻO kēia hemahema ka mea e hoʻoneʻe ai i kona waiwai, e lilo ia i mea waiwai nui loa i nā huahana mālama ʻili, e like me ke gula. ʻO ke kumu kūʻai o 90% mea maʻemaʻe maʻemaʻe o kēia mea e piʻi aʻe ma luna o 200,000 yuan / kg.
Pīhoihoi au, no laila ua kipa au i ka pūnaewele Aladdin e hōʻoia i nā kikoʻī. Hāʻawi ʻia ka laikini analytically pure (purity ≥99%) ma ke kumu kūʻai hoʻolaha o 780 yuan/20mg, e like me 39,000 yuan/g.
I ka manawa koke, ua loaʻa iaʻu kahi mahalo hou no kēia mea hoʻohui ʻole. Ua loaʻa iā ia ke poʻo inoa o ka "whitening gold" a i ʻole "Golden Whitener".

No.3 He aha ka hana o Glabridin?

Hāʻawi ʻo Glabridin i ka nui o nā waiwai olaola. He mea hoʻohana maikaʻi, palekana, a me ke kaiapuni no ka keʻokeʻo a me ka wehe ʻana i ka freckle. Eia kekahi, loaʻa iā ia ka antibacterial, anti-inflammatory, antioxidant, anti-aging, a me nā hopena anti-ultraviolet. Kākoʻo ʻia kona mana maikaʻi loa i ka hoʻomaʻemaʻe ʻana, ka hoʻomaʻamaʻa ʻana, a me ka wehe ʻana i nā freckle e ka ʻikepili hoʻokolohua, e hōʻike ana i ka hopena keʻokeʻo o Glabridin ma mua o ko ka vitamina C ma mua o 230 mau manawa, hydroquinone e 16 mau manawa, a me ka mea hoʻomaʻemaʻe kaulana kaulana arbutin e kahi mea kupanaha 1164. manawa.

No.4 He aha ka hana keʻokeʻo o glabridin?

Ke ʻike ʻia ka ʻili i nā kukuna ultraviolet, e hoʻoulu ai i ka hana ʻana o nā radical manuahi, hoʻoulu ʻia nā melanocytes e hana i ka tyrosinase. Ma lalo o ka mana o kēia enzyme, hoʻohua ka tyrosine i ka ʻili i ka melanin, e alakaʻi ana i ka pōʻeleʻele o ka ʻili ke lawe ʻia ka melanin mai ka papa basal a i ka stratum corneum.
ʻO ke kumu kumu o kēlā me kēia mea keʻokeʻo ke komo i ke kaʻina hana o ka hoʻokumu ʻana o ka melanin a i ʻole ka lawe ʻana. ʻO ka hana keʻokeʻo a Glabridin e hoʻopili nui i nā ʻano ʻekolu:
(1) Kāohi i ka hana tyrosinase
Hōʻike ʻo Glabridin i kahi hopena paʻa paʻa i ka hana tyrosinase, e hāʻawi ana i nā hopena maopopo a koʻikoʻi. Hōʻike nā hoʻohālikelike kamepiula e hiki i ka glabridin ke hoʻopaʻa paʻa i ke kikowaena ikaika o tyrosinase ma o nā paʻa hydrogen, me ka pale pono ʻana i ke komo ʻana o ka mea maka no ka hana melanin (tyrosine), a laila e pale ai i ka hana melanin. ʻO kēia ala, i kapa ʻia ʻo ka hoʻokūkū hoʻokūkū, ua like ia me kahi ʻano aloha aloha wiwo ʻole.

(2) Kāohi ʻana i ka hana o nā ʻano oxygen reactive (antioxidant)
ʻO ka ʻike ʻana i nā kukuna ultraviolet e hoʻoulu i ka hana ʻana i nā ʻano oxygen reactive (nā radical manuahi), hiki ke hōʻino i ka membrane phospholipid o ka ʻili, e hopena i ka erythema a me ka pigmentation. No laila, ʻike ʻia nā ʻano oxygen reactive e hāʻawi i ka pigmentation ʻili, e hōʻike ana i ke koʻikoʻi o ka pale ʻana i ka lā i ka mālama ʻili. Ua hōʻike ʻia nā haʻawina hoʻokolohua e hōʻike ana ʻo glabridin i nā mana hoʻoheheʻe radical manuahi e like me ka superoxide dismutase (SOD), e hana ana ma ke ʻano he antioxidant. Mālama kēia i ka hoʻohaʻahaʻa i nā kumu e hoʻonui ai i ka hana tyrosinase.

(3) Kāohi ʻana i ka mumū
Ma hope o ka pōʻino o ka ʻili mai nā kukuna ultraviolet, ke ʻano o ka erythema a me ka pigmentation e hele pū me ka mumū, e hoʻonui hou i ka hana melanin a hoʻomau i kahi pōʻai pōʻino. Hoʻokumu nā waiwai anti-inflammatory a Glabridin i kahi ʻano kūpono no ka pale ʻana i ka hoʻokumu ʻana o ka melanin i kekahi ʻano, ʻoiai e paipai ana i ka hoʻoponopono ʻana i ka ʻili i hōʻino ʻia.

No. 5 He Mana Loa ʻo Glabridin?

Ua hoʻomaikaʻi ʻia ʻo Glabridin ma ke ʻano he mea hoʻonaninani maikaʻi a pili i ke kaiapuni no ka hoʻomaʻemaʻe ʻana a me ka wehe ʻana i ka freckle, e kaena ana i kahi mīkini keʻokeʻo i wehewehe maikaʻi ʻia a me ka maikaʻi kupaianaha. Hōʻike ka ʻikepili hoʻokolohua ʻoi aku kona hopena keʻokeʻo ma mua o ka arbutin "whitening giant" ma mua o hoʻokahi kaukani manawa (e like me ka hōʻike ʻana i ka ʻikepili hoʻokolohua).
Ua hana nā mea noiʻi i kahi hoʻohālike hoʻokolohua holoholona me ka hoʻohana ʻana i ka zebrafish e loiloi i ka hopena pale o glabridin ma ka melanin, e hōʻike ana i kahi hoʻohālikelike koʻikoʻi me ka kojic acid a me ka bearberry.
Ma kahi o nā hoʻokolohua holoholona, ua hōʻike pū nā hopena lapaʻau i ka hopena keʻokeʻo koʻikoʻi o glabridin, me nā hopena i ʻike ʻia i loko o 4-8 mau pule.
ʻOiai ua ʻike ʻia ka maikaʻi o kēia mea keʻokeʻo, ʻaʻole i laha loa kona hoʻohana ʻana e like me nā mea ʻē aʻe. I koʻu manaʻo, aia ke kumu nui i kona "kūlana gula" i ka ʻoihana—he pipiʻi! Eia nō naʻe, ma hope o ka hoʻohana ʻana i nā huahana mālama ʻili maʻamau, ke ulu nui nei ka poʻe e ʻimi nei i nā huahana i loaʻa kēia mea "gula".

No.6 ʻO wai nā huahana mālama ʻili i loaʻa iā Glabridin?

Hoʻokuʻu: He papa inoa kēia, ʻaʻole he manaʻo!
ʻO Glabridin kahi mea mālama ʻili ikaika i ʻike ʻia no kāna mau mea hoʻomālamalama ʻili. Hiki ke loaʻa i nā huahana mālama ʻili like ʻole, me nā serums, essences, lotions, a me nā masks. ʻO kekahi mau huahana kikoʻī i loaʻa paha iā Glabridin, akā naʻe, he mea nui e hoʻomaopopo he ʻokoʻa paha ka noho ʻana o Glabridin i nā huahana mālama ʻili, a pono e nānā pono i nā papa inoa o nā huahana kikoʻī e ʻike ai i kona komo ʻana.
(1) Aleble Licorice Queen Lotion Kino
Hōʻike nui ʻia ka papa inoa o ka "Glycyrrhiza glabra" ma ke ʻano he lua (ma hope o ka wai), me ka glycerin, sodium hyaluronate, squalane, ceramide, a me nā mea moisturizing ʻē aʻe.
(2) Hoʻomaʻamaʻa ʻana i ka wai ʻono o nā keiki i nā hua licorice māmā
ʻO nā mea koʻikoʻi he Glycyrrhiza glabra extract, hydrolyzed algae extract, arbutin, Polygonum cuspidatum root extract, Scutellaria baicalensis root extract, a ʻoi aku.
(3) Kokoskin Snow Clock Essence Body Serum
E hōʻike ana i ka 5% nicotinamide, 377, a me glabridin ma kāna mau mea nui.
4
ʻOkoʻa kēia ʻano o nā huahana, me ka liʻiliʻi o kekahi a kūʻai ʻia ma ke ʻano he lāʻau "glabragan."
(5) Guyu Licorice Series

No.7 Hoehaeha uhane

(1) Ua lawe maoli ʻia ka Glabridin i nā huahana mālama ʻili mai ka licorice?
ʻO ka nīnau inā paha i lawe ʻia ʻo Glabridin i nā huahana mālama ʻili mai ka licorice he mea kūpono. He ʻokoʻa ke ʻano kemika o ka licorice extract, ʻoi aku ka glabridin, a he kumu kūʻai paha ke kaʻina hana. Hoʻoulu kēia i ka nīnau inā paha e ʻoi aku ka maʻalahi o ka noʻonoʻo ʻana i ka synthesis kemika ma ke ʻano he ala ʻē aʻe no ka loaʻa ʻana o glabridin. ʻOiai hiki ke loaʻa i kekahi mau pūhui, e like me artemisinin, ma o ka hoʻohuihui ʻana, hiki ke hoʻohui pū i ka glabridin. Eia nō naʻe, pono e noʻonoʻo ʻia nā kumu kūʻai o ka synthesis kemika i hoʻohālikelike ʻia me ka unuhi. Eia kekahi, aia paha nā hopohopo e pili ana i ka hoʻohana manaʻo ʻana i ka lepili "Glycyrrhiza glabra extract" i loko o nā papa inoa o nā huahana mālama ʻili e hana i kahi hoʻopiʻi kūʻai ʻana mea kūlohelohe. He mea nui e ʻimi i ke kumu a me nā ʻano hana o nā mea mālama ʻili e hōʻoia i ka ʻike a me ka ʻoiaʻiʻo.

(2) Hiki iaʻu ke hoʻopili pololei i ka licorice maʻemaʻe kiʻekiʻe ma koʻu mau maka no ka ʻili keʻokeʻo hau?
ʻO ka pane he ʻaʻole! ʻOiai mahalo ʻia ka hopena keʻokeʻo o glabridin, ua kaupalena kona mau waiwai i kāna noi pololei. ʻAʻole hiki ke hoʻoheheʻe ʻia ʻo Glycyrrhizin i ka wai, a nāwaliwali kona hiki ke komo i ka pale ʻili. ʻO ka hoʻokomo ʻana i loko o nā huahana mālama ʻili e pono ai ka hana ikaika a me ka hoʻomākaukau ʻana. Me ka ʻole o ka hoʻokumu pono ʻana, he mea paʻakikī ke hoʻokō i ka hopena i makemake ʻia. Eia nō naʻe, ua alakaʻi ka noiʻi ʻepekema i ka hoʻomohala ʻana i nā hoʻomākaukau topical ma ke ʻano o nā liposomes, hoʻonui i ka absorption a me ka hoʻohana ʻana o glabridin ma o ka ʻili.

nā kuhikuhi:
[1] Pigmentation: dyschromia[M]. ʻO Thierry Passeron lāua ʻo Jean-Paul Ortonne, 2010.
[2] J. Chen et al. / Spectrochimica Acta Māhele A: Molecular and Biomolecular Spectroscopy 168 (2016) 111–117