I ka wā e ʻelemakule ai ka ʻili, aia ka emi ʻana o ka hana physiologic. Hoʻoulu ʻia kēia mau loli e nā kumu intrinsic (chronologic) a me extrinsic (ʻoi aku ka nui o ka UV-induced). Hāʻawi nā botanicals i nā pono kūpono e hakakā ai i kekahi o nā hōʻailona o ka ʻelemakule. Maanei, ke nānā nei mākou i kekahi mau botanicals a me nā hōʻike ʻepekema ma hope o kā lākou mau koi anti-aging. Hiki i nā botanicals ke hāʻawi i nā hopena anti-inflammatory, antioxidant, moisturizing, UV-protection, a me nā hopena ʻē aʻe. He nui nā botanicals i helu ʻia he mau mea hoʻohui i nā mea hoʻonani kaulana a me nā cosmeceuticals, akā he kakaikahi wale nō i kūkākūkā ʻia ma aneʻi. Ua koho ʻia kēia mau mea ma muli o ka loaʻa ʻana o ka ʻikepili ʻepekema, ka hoihoi pilikino o nā mea kākau, a me ka "kaulana" i ʻike ʻia o nā huahana hoʻonani a me nā cosmeceutical o kēia manawa. ʻO nā botanicals i loiloi ʻia ma aneʻi e komo pū me ka ʻaila argan, ka ʻaila niu, crocin, feverfew, kī ʻōmaʻomaʻo, marigold, pomegranate, a me ka soy.
Nā huaʻōlelo: botanical; anti-aging; ʻaila argan; ʻaila niu; crocin; feverfew; kī ʻōmaʻomaʻo; marigold; pomegerane; soy
3.1. ʻAila ʻArgan
3.1.1. Mōʻaukala, Hoʻohana, a me nā Koi
He ʻaila Argan ka ʻaila maoli ma Morocco a ua hana ʻia mai nā hua o Argania sponosa L. He nui kona mau hoʻohana kuʻuna e like me ka kuke ʻana, ka mālama ʻana i nā maʻi ʻili, a me ka mālama ʻana i ka ʻili a me ka lauoho.
3.1.2. Ka Hoʻonohonoho ʻana a me ke ʻAno Hana
ʻO ka ʻaila Argan he 80% ka momona monounsaturated a me 20% saturated fatty acids a loaʻa iā ia nā polyphenols, tocopherols, sterols, squalene, a me ka triterpene alcohol.
3.1.3. Nā Hōʻike ʻEpekema
Ua hoʻohana maʻamau ʻia ka ʻaila Argan ma Morocco e hōʻemi i ka pigmentation o ka maka, akā ʻaʻole i maopopo mua ke kumu ʻepekema no kēia koi. Ma kahi noiʻi ʻiole, ua kāohi ka ʻaila argan i ka tyrosinase a me ka dopachrome tautomerase expression i loko o nā cell melanoma B16 murine, e hopena ana i ka emi ʻana o ka nui o ka melanin. Hōʻike kēia he mea hoʻopaʻa ikaika paha ka ʻaila argan i ka biosynthesis melanin, akā pono nā hoʻokolohua hoʻomalu randomized (RTC) i nā kānaka e hōʻoia i kēia kuhiakau.
Ua hōʻike ʻia kahi RTC liʻiliʻi o 60 mau wahine post-menopausal e hōʻemi ana ka hoʻohana ʻana i kēlā me kēia lā a/a i ʻole ka hoʻopili ʻana o ka ʻaila argan i ka nalowale wai transepidermal (TEWL), hoʻomaikaʻi i ka elasticity o ka ʻili, ma muli o ka hoʻonui ʻana o R2 (elasticity nui o ka ʻili), R5 (elasticity net o ka ʻili), a me R7 (elasticity biological) parameters a me ka emi ʻana o ka manawa holo resonance (RRT) (kahi ana e pili ana i ka elasticity ʻili). Ua hoʻokaʻawale ʻia nā hui e hoʻopau i ka ʻaila ʻoliva a i ʻole ka ʻaila argan. Ua hoʻopili nā hui ʻelua i ka ʻaila argan i ka pulima volar hema wale nō. Ua lawe ʻia nā ana mai nā pulima volar ʻākau a me hema. Ua ʻike ʻia nā hoʻomaikaʻi ʻana i ka elasticity i nā hui ʻelua ma ka pulima kahi i hoʻopili ʻia ai ka ʻaila argan ma ke ʻano topical, akā ma ka pulima kahi i hoʻopili ʻole ʻia ai ka ʻaila argan ʻo ka hui wale nō e hoʻopau ana i ka ʻaila argan i loaʻa ka piʻi nui o ka elasticity [31]. Ua pili kēia i ka hoʻonui ʻia o ka nui o ka antioxidant i loko o ka ʻaila argan i hoʻohālikelike ʻia me ka ʻaila ʻoliva. Ua manaʻo ʻia he hiki ke kumu kēia o kāna Vitamin E a me ka ferulic acid content, ʻo ia hoʻi nā antioxidants i ʻike ʻia.
3.2. ʻAila niu
3.2.1. Mōʻaukala, Hoʻohana, a me nā Koi
Loaʻa ka ʻaila niu mai ka hua maloʻo o Cocos nucifera a he nui nā hoʻohana, ʻo ia hoʻi ka wā kahiko a me kēia au. Ua hoʻohana ʻia ia ma ke ʻano he mea ʻala, mea hoʻomaʻemaʻe ʻili, a me ka lauoho, a ma nā huahana hoʻonani he nui. ʻOiai he nui nā mea i loaʻa i ka ʻaila niu, me ka waikawa niu, ka waikawa niu hydrogenated, a me ka ʻaila niu hydrogenated, e kūkākūkā mākou i nā koi noiʻi e pili nui ana me ka ʻaila niu puʻupaʻa (VCO), i hoʻomākaukau ʻia me ka ʻole o ka wela.
Ua hoʻohana ʻia ka ʻaila niu no ka hoʻomaʻū ʻana i ka ʻili o ka pēpē a he mea pono paha ia i ka mālama ʻana i ka dermatitis atopic no kona mau waiwai hoʻomaʻū a me kona hopena kūpono ma Staphylococcus aureus a me nā microbes ʻili ʻē aʻe i nā maʻi atopic. Ua hōʻike ʻia ka ʻaila niu e hōʻemi i ka kolone ʻana o S. aureus ma ka ʻili o nā pākeke me ka dermatitis atopic i loko o kahi RTC makapō pālua.
3.2.2. Ka Hoʻonohonoho ʻana a me ke ʻAno Hana
Ua haku ʻia ka ʻaila niu me 90–95% saturated triglycerides (lauric acid, myristic acid, caprylic acid, capric acid, a me palmitic acid). He ʻokoʻa kēia i ka hapa nui o nā ʻaila mea kanu/huaʻai, kahi i haku nui ʻia me ka momona unsaturated. Hana nā saturated triglycerides i hoʻopili ʻia ma luna o ka ʻili e hoʻomaʻū i ka ʻili ma ke ʻano he emollient ma ka hoʻopālahalaha ʻana i nā kihi maloʻo a ʻōwili o nā corneocytes a hoʻopiha i nā hakahaka ma waena o lākou.
3.2.3. Nā Hōʻike ʻEpekema
Hiki i ka ʻaila niu ke hoʻomaʻū i ka ʻili maloʻo a ʻelemakule. He like ka lōʻihi o nā waikawa momona he kanaono kumamālua pakeneka o ka VCO a he 92% ka momona, kahi e ʻae ai i ka hoʻopaʻa paʻa ʻana e hopena i ka hopena occlusive nui aʻe ma mua o ka ʻaila ʻoliva. Hoʻokaʻawale ʻia nā triglycerides i loko o ka ʻaila niu e nā lipases i loko o ka flora ʻili maʻamau i ka glycerin a me nā waikawa momona. He humectant ikaika ʻo Glycerin, kahi e huki ai i ka wai i ka papa corneal o ka epidermis mai ke kaiapuni waho a me nā papa ʻili hohonu. He haʻahaʻa ka nui o ka waikawa linoleic i loko o nā waikawa momona i loko o VCO, he mea nui ia no ka mea hiki i ka waikawa linoleic ke hoʻonāukiuki i ka ʻili. ʻOi aku ka maikaʻi o ka ʻaila niu ma mua o ka ʻaila mineral i ka hoʻemi ʻana i ka TEWL i nā poʻe maʻi me ka atopic dermatitis a he like ka maikaʻi a me ka palekana e like me ka ʻaila mineral i ka mālama ʻana i ka xerosis.
ʻO ka waikawa Lauric, kahi mea i hoʻokumu ʻia i ka monolaurin a me kahi ʻāpana koʻikoʻi o VCO, loaʻa paha nā waiwai anti-inflammatory, hiki ke hoʻololi i ka hoʻonui ʻana o nā cell immune a kuleana no kekahi o nā hopena antimicrobial o VCO. Loaʻa i ka VCO nā pae kiʻekiʻe o ka waikawa ferulic a me ka waikawa p-coumaric (ʻelua mau waikawa phenolic), a ʻo nā pae kiʻekiʻe o kēia mau waikawa phenolic e pili ana me ka hoʻonui ʻia o ka mana antioxidant. He kūpono nā waikawa Phenolic e kūʻē i ka pōʻino i hoʻokumu ʻia e UV. Eia nō naʻe, me ka ʻole o nā koi e hiki i ka ʻaila niu ke hana ma ke ʻano he sunscreen, hōʻike nā haʻawina in vitro he liʻiliʻi a ʻaʻohe paha ka hiki ke pale aku i ka UV.
Ma waho aʻe o kona hopena moisturizing a me antioxidant, hōʻike nā hiʻohiʻona holoholona e hiki i ka VCO ke hōʻemi i ka manawa ho'ōla ʻeha. Ua piʻi aʻe ka pae o ka pepsin-soluble collagen (ʻoi aku ka kiʻekiʻe o ka collagen cross-linking) i nā ʻeha i mālama ʻia e VCO i hoʻohālikelike ʻia me nā kaohi. Ua hōʻike ka Histopathology i ka hoʻonui ʻia ʻana o ka fibroblast proliferation a me ka neovascularization i loko o kēia mau ʻeha. Pono nā haʻawina hou aʻe e ʻike ai inā hiki i ka hoʻopili ʻana o VCO ma luna o ka ʻili ke hoʻonui i nā pae collagen i ka ʻili kanaka e ʻelemakule ana.
3.3. ʻO ke Koloka
3.3.1. Mōʻaukala, Hoʻohana, Nā Koi
He ʻāpana hana olaola ka Crocin o ka saffron, i loaʻa mai ka stigma maloʻo o Crocus sativus L. Ua mahi ʻia ka Saffron ma nā ʻāina he nui e like me Iran, India, a me Helene, a ua hoʻohana ʻia i ka lāʻau lapaʻau kuʻuna e hōʻoluʻolu i nā ʻano maʻi like ʻole me ke kaumaha, ka mumū, nā maʻi akepaʻa, a me nā mea ʻē aʻe he nui.
3.3.2. Ka Hoʻonohonoho ʻana a me ke ʻAno Hana
ʻO ke crocin ke kuleana no ke kala o ka saffron. Loaʻa pū ke crocin i loko o ka hua o Gardenia jasminoides Ellis. Ua hoʻokaʻawale ʻia ʻo ia he carotenoid glycoside.
3.3.3. Nā Hōʻike ʻEpekema
Loaʻa iā Crocin nā hopena antioxidant, pale i ka squalene mai ka peroxidation i hoʻokomo ʻia e ka UV, a pale i ka hoʻokuʻu ʻana o nā mea hoʻopili mumū. Ua hōʻike ʻia ka hopena antioxidant i nā hoʻāʻo in vitro i hōʻike i ka hana antioxidant kiʻekiʻe i hoʻohālikelike ʻia me ka Vitamin C. Eia kekahi, pale ʻo crocin i ka peroxidation membrane cell i hoʻokomo ʻia e ka UVA a pale i ka hōʻike ʻana o nā mea hoʻopili pro-inflammatory he nui e like me IL-8, PGE-2, IL-6, TNF-α, IL-1α, a me LTB4. Hoʻemi pū ia i ka hōʻike ʻana o nā genes NF-κB he nui. Ma kahi noiʻi e hoʻohana ana i nā fibroblasts kanaka i hoʻoulu ʻia, ua hoʻemi ʻo crocin i ka ROS i hoʻokomo ʻia e ka UV, hoʻolaha i ka hōʻike ʻana o ka protein matrix extracellular Col-1, a hoʻemi i ka helu o nā cell me nā phenotypes senescent ma hope o ka radiation UV. Hoʻemi ia i ka hana ROS a kaupalena i ka apoptosis. Ua hōʻike ʻia ʻo Crocin e kāohi i nā ala hōʻailona ERK/MAPK/NF-κB/STAT i nā cell HaCaT in vitro. ʻOiai he hiki i ka crocin ke lilo i cosmeceutical anti-aging, ʻaʻole paʻa ka hui. Ua noiʻi ʻia ka hoʻohana ʻana i nā nanostructured lipid dispersions no ka hoʻokele topical me nā hopena hoʻohiki. No ka hoʻoholo ʻana i nā hopena o ka crocin in vivo, pono nā hiʻohiʻona holoholona hou a me nā hoʻokolohua lapaʻau randomized.
3.4. Feverfew
3.4.1. Mōʻaukala, Hoʻohana, Nā Koi
ʻO ka Feverfew, a i ʻole Tanacetum parthenium, he mea kanu mau ia i hoʻohana ʻia no nā kumu he nui i ka lāʻau lapaʻau kuʻuna.
3.4.2. Ka Hoʻonohonoho ʻana a me ke ʻAno Hana
Loaʻa i loko o Feverfew ka parthenolide, kahi sesquiterpene lactone, ka mea paha ke kuleana no kekahi o kāna mau hopena anti-inflammatory, ma o ka pale ʻana o NF-κB. ʻIke ʻia kēia pale ʻana o NF-κB he kūʻokoʻa ia mai nā hopena antioxidant o ka parthenolide. Ua hōʻike pū ʻo Parthenolide i nā hopena anticancer e kūʻē i ka maʻi ʻili i hoʻokomo ʻia e UVB a kūʻē i nā cell melanoma in vitro. ʻO ka mea pōʻino, hiki i ka parthenolide ke hana i nā hopena allergic, nā pehu waha, a me ka dermatitis contact allergic. Ma muli o kēia mau hopohopo, ua wehe ʻia i kēia manawa ma mua o ka hoʻohui ʻia ʻana o ka feverfew i nā huahana hoʻonani.
3.4.3. Nā Hōʻike ʻEpekema
Ma muli o nā pilikia hiki ke loaʻa me ka hoʻohana ʻana o ka parthenolide ma ke ʻano topical, hoʻohana kekahi mau huahana hoʻonani o kēia manawa i loaʻa ka feverfew i ka parthenolide-depleted feverfew (PD-feverfew), ka mea e ʻōlelo nei ʻaʻohe ona hiki ke hoʻonui i ka sensitization. Hiki i ka PD-feverfew ke hoʻonui i ka hana hoʻoponopono DNA endogenous i loko o ka ʻili, e hōʻemi ana i ka hōʻino DNA i hoʻokomo ʻia e UV. Ma kahi noiʻi in vitro, ua hoʻēmi ka PD-feverfew i ka hoʻokumu ʻana o ka hydrogen peroxide i hoʻokomo ʻia e UV a ua hoʻemi i ka hoʻokuʻu ʻana o ka cytokine pro-inflammatory. Ua hōʻike ʻo ia i nā hopena antioxidant ikaika aʻe ma mua o ka mea hoʻohālikelike, ʻo Vitamin C, a ua hoʻemi i ka erythema i hoʻokomo ʻia e UV i loko o kahi RTC 12-subject.
3.5. Kī ʻōmaʻomaʻo
3.5.1. Mōʻaukala, Hoʻohana, Nā Koi
Ua inu ʻia ke kī ʻōmaʻomaʻo no kona mau pono olakino ma Kina no nā kenekulia. Ma muli o kona hopena antioxidant ikaika, aia ka hoihoi i ka hoʻomohala ʻana i kahi ʻano paʻa a bioavailable topical.
3.5.2. Ka Hoʻonohonoho ʻana a me ke ʻAno Hana
ʻO ke kī ʻōmaʻomaʻo, mai Camellia sinensis, aia nā hui bioactive he nui me nā hopena anti-aging hiki, me ka caffeine, nā huaora, a me nā polyphenols. ʻO nā polyphenols nui i loko o ke kī ʻōmaʻomaʻo he catechins, ʻo ia hoʻi ka gallocatechin, epigallocatechin (ECG), a me ka epigallocatechin-3-gallate (EGCG). Loaʻa i ka Epigallocatechin-3-gallate nā waiwai antioxidant, photoprotective, immunomodulatory, anti-angiogenic, a me anti-inflammatory. Loaʻa pū i ke kī ʻōmaʻomaʻo ka nui o ka flavonol glycoside kaempferol, kahi i omo maikaʻi ʻia i loko o ka ʻili ma hope o ka hoʻopili ʻana ma luna o ka ʻili.
3.5.3. Nā Hōʻike ʻEpekema
Hoʻemi ka ʻāpana kī ʻōmaʻomaʻo i ka hana ROS intracellular in vitro a ua hoʻemi i ka necrosis i hoʻokomo ʻia e ROS. Hoʻopale ʻo Epigallocatechin-3-gallate (kahi polyphenol kī ʻōmaʻomaʻo) i ka hoʻokuʻu ʻana o ka hydrogen peroxide i hoʻokomo ʻia e UV, kāohi i ka phosphorylation o MAPK, a hoʻemi i ka mumū ma o ka hoʻoulu ʻana o NF-κB. Ma ka hoʻohana ʻana i ka ʻili ex vivo mai kahi wahine olakino 31 makahiki, ua hōʻike ka ʻili i mālama mua ʻia me ka ʻāpana kī keʻokeʻo a ʻōmaʻomaʻo paha i ka paʻa ʻana o nā cell Langerhans (nā cell antigen-presenting ke kuleana no ka hoʻokomo ʻana i ka pale ʻana i ka ʻili) ma hope o ka hōʻike ʻana i ka mālamalama UV.
I loko o kahi kumu hoʻohālike ʻiole, ʻo ka hoʻopili ʻana o ka ʻōmole kī ʻōmaʻomaʻo ma mua o ka hōʻike ʻana o ka UV i alakaʻi i ka emi ʻana o ka erythema, ka emi ʻana o ke komo ʻana o nā leukocytes i ka ʻili, a me ka emi ʻana o ka hana myeloperoxidase. Hiki iā ia ke kāohi i ka 5-α-reductase.
Ua loiloi kekahi mau haʻawina e pili ana i nā kumuhana kanaka i nā pono kūpono o ka hoʻopili ʻana o ke kī ʻōmaʻomaʻo ma luna o ka ʻili. Ua kāohi ka hoʻopili ʻana o kahi emulsion kī ʻōmaʻomaʻo i ka 5-α-reductase a ua alakaʻi i ka emi ʻana o ka nui o ka microcomedone i ka microcomedonal acne. Ma kahi noiʻi liʻiliʻi ʻeono pule o ke kanaka, ua hoʻemi kahi kirīmi i loaʻa iā EGCG i ka hypoxia-inducible factor 1 α (HIF-1α) a me ka vascular endothelial growth factor (VEGF) expression, e hōʻike ana i ka hiki ke pale aku i nā telangiectasias. Ma kahi noiʻi pālua makapō, ua hoʻopili ʻia ke kī ʻōmaʻomaʻo, ke kī keʻokeʻo, a i ʻole kaʻa wale nō i nā puʻupuʻu o 10 mau mea manawaleʻa olakino. A laila ua hoʻomālamalama ʻia ka ʻili me ka 2 × minimal erythema dose (MED) o ka solar-simulated UVR. Ua hōʻike nā biopsies ʻili mai kēia mau wahi e hiki i ka hoʻopili ʻana o ka ʻōmaʻomaʻo a i ʻole keʻokeʻo ke hoʻemi nui i ka hoʻopau ʻana o nā cell Langerhans, ma muli o ka CD1a positivity. Aia kekahi pale hapa o ka hōʻino DNA oxidative i hoʻokomo ʻia e UV, e like me ka hōʻike ʻana e ka emi ʻana o nā pae o 8-OHdG. Ma kahi noiʻi ʻokoʻa, ua hoʻokaʻawale ʻia he 90 mau mākua manawaleʻa i ʻekolu mau pūʻulu: ʻAʻohe lāʻau lapaʻau, kī ʻōmaʻomaʻo topical, a i ʻole kī keʻokeʻo topical. Ua māhele hou ʻia kēlā me kēia hui i nā pae like ʻole o ka radiation UV. Ua ʻike ʻia ka mea pale lā in vivo ma kahi o SPF 1.
3.6. ʻO Marigold
3.6.1. Mōʻaukala, Hoʻohana, Nā Koi
ʻO Marigold, Calendula officinalis, he mea kanu pua ʻala me nā hiki ke hoʻōla. Ua hoʻohana ʻia ia i ka lāʻau lapaʻau kuʻuna ma ʻEulopa a me ʻAmelika Hui Pū ʻIa ma ke ʻano he lāʻau lapaʻau topical no nā kuni, nā palapū, nā ʻoki, a me nā ʻulaʻula. Ua hōʻike pū ʻo Marigold i nā hopena anticancer i nā hiʻohiʻona murine o ka maʻi ʻili non-melanoma.
3.6.2. Ka Hoʻonohonoho ʻana a me ke ʻAno Hana
ʻO nā mea kemika nui o nā marigolds he steroids, terpenoids, free and esterified triterpene alcohols, phenolic acids, flavonoids, a me nā hui ʻē aʻe. ʻOiai ua hōʻike kekahi noiʻi e hiki i ka hoʻopili ʻana o ka marigold extract ke hōʻemi i ke koʻikoʻi a me ka ʻeha o ka radiation dermatitis i nā poʻe maʻi e loaʻa ana i ka radiation no ka maʻi ʻaʻai umauma, ʻaʻole i hōʻike nā hoʻokolohua lapaʻau ʻē aʻe i kahi ʻoi aku ka maikaʻi ke hoʻohālikelike ʻia me ka hoʻopili ʻana o ka wai kirīmi wale nō.
3.6.3. Nā Hōʻike ʻEpekema
Loaʻa iā Marigold kahi hiki ke antioxidant a me nā hopena cytotoxic i nā cell cancer kanaka i loko o kahi kumu hoʻohālike cell ʻili kanaka in vitro. Ma kahi noiʻi in vitro kaʻawale, ua loiloi ʻia kahi kirīmi e loaʻa ana ka ʻaila calendula ma o ka UV spectrophotometric a ua ʻike ʻia he spectrum absorbance ma ka laulā o 290-320 nm; ua lawe ʻia kēia e hōʻike ana ua hāʻawi ka hoʻopili ʻana o kēia kirīmi i ka pale lā maikaʻi. Eia naʻe, he mea nui e hoʻomaopopo ʻaʻole kēia he hoʻāʻo in vivo i helu i ka liʻiliʻi o ka erythema dose i nā mea manawaleʻa kanaka a ʻaʻole maopopo pehea e unuhi ʻia ai kēia i nā hoʻokolohua lapaʻau.
I loko o kahi kumu hoʻohālike murine in vivo, ua hōʻike ka ʻāpana marigold i kahi hopena antioxidant ikaika ma hope o ka hōʻike ʻana i ka UV. Ma kahi noiʻi ʻokoʻa, e pili ana i nā ʻiole albino, ua hōʻemi ka hoʻopili ʻana o ka ʻaila koʻikoʻi calendula i ka malondialdehyde (kahi māka o ke kaumaha oxidative) ʻoiai e hoʻonui ana i nā pae o ka catalase, glutathione, superoxide dismutase, a me ka ascorbic acid i loko o ka ʻili.
I loko o kahi noiʻi makapō hoʻokahi ʻewalu pule me 21 mau kumuhana kanaka, ʻo ka hoʻopili ʻana o ka kirīmi calendula i nā papālina ua hoʻonui i ka paʻa o ka ʻili akā ʻaʻohe hopena koʻikoʻi i ka elasticity o ka ʻili.
ʻO kahi palena kūpono i ka hoʻohana ʻana i ka marigold i nā mea hoʻonani, ʻo ia ka marigold kahi kumu i ʻike ʻia o ka dermatitis pili maʻi, e like me nā lālā ʻē aʻe o ka ʻohana Compositae.
3.7. Pomegerane
3.7.1. Mōʻaukala, Hoʻohana, Nā Koi
ʻO ka pomegranate, ʻo Punica granatum, he mana antioxidant ikaika a ua hoʻohana ʻia i loko o nā huahana he nui ma ke ʻano he antioxidant topical. ʻO kona ʻike antioxidant kiʻekiʻe e lilo ia i mea hoihoi i nā ʻano hoʻonaninani.
3.7.2. Ka Hoʻonohonoho ʻana a me ke ʻAno Hana
ʻO nā mea hana olaola o ka pomegranate he tannins, anthocyanins, ascorbic acid, niacin, potassium, a me nā piperidine alkaloids. Hiki ke unuhi ʻia kēia mau mea hana olaola mai ka wai, nā hua, ka ʻili, ka ʻili lāʻau, ke aʻa, a i ʻole ke kumu o ka pomegranate. Manaʻo ʻia kekahi o kēia mau mea he antitumor, anti-inflammatory, anti-microbial, antioxidant, a me nā hopena photoprotective. Eia kekahi, he kumu ikaika ka pomegranate o nā polyphenols. ʻO ka waikawa Ellegic, kahi ʻāpana o ka extract pomegranate, hiki ke hoʻemi i ka pigmentation ʻili. Ma muli o ka lilo ʻana i mea hoʻohiki anti-aging, ua noiʻi nā haʻawina he nui i nā ʻano e hoʻonui ai i ka komo ʻana o ka ʻili o kēia hui no ka hoʻohana topical.
3.7.3. Nā Hōʻike ʻEpekema
Mālama ka ʻāpana hua pomegranate i nā fibroblasts kanaka, in vitro, mai ka make ʻana o nā cell i hoʻokomo ʻia e UV; ma muli paha o ka emi ʻana o ka hoʻoulu ʻana o NF-κB, ka hoʻohaʻahaʻa ʻana o ka proapoptotic caspace-3, a me ka hoʻonui ʻana i ka hoʻoponopono DNA. Hōʻike ia i nā hopena hoʻolaha anti-skin-tumor in vitro a kāohi i ka modulation UVB-induced o nā ala NF-κB a me MAPK. ʻO ka hoʻopili ʻana o ka ʻāpana rind pomegranate e hoʻohaʻahaʻa i ka COX-2 i loko o ka ʻili porcine i unuhi hou ʻia, e hopena ana i nā hopena anti-inflammatory koʻikoʻi. ʻOiai ua manaʻo pinepine ʻia ka waikawa ellegic ʻo ia ka mea hana nui loa o ka ʻāpana pomegranate, ua hōʻike kahi kumu hoʻohālike murine i ka hana anti-inflammatory kiʻekiʻe me ka ʻāpana rind pomegranate maʻamau i hoʻohālikelike ʻia me ka waikawa ellegic wale nō. ʻO ka hoʻopili ʻana o ka microemulsion o ka ʻāpana pomegranate me ka hoʻohana ʻana i kahi surfactant polysorbate (Tween 80®) i loko o kahi hoʻohālikelike maka māhele 12-pule me 11 mau kumuhana, ua hōʻike i ka emi ʻana o ka melanin (ma muli o ka tyrosinase inhibition) a me ka emi ʻana o ka erythema i hoʻohālikelike ʻia me ka kaohi kaʻa.
3.8. Soy
3.8.1. Mōʻaukala, Hoʻohana, Nā Koi
He meaʻai kiʻekiʻe ka protein o nā pīni soya me nā mea bioactive e loaʻa paha nā hopena anti-aging. ʻOi aku ka nui, he kiʻekiʻe nā isoflavones o nā pīni soya, nona paha nā hopena anticarcinogenic a me nā hopena estrogen-like ma muli o ke ʻano diphenolic. Hiki i kēia mau hopena estrogen-like ke hakakā i kekahi o nā hopena o ka menopause ma ka ʻelemakule ʻili.
3.8.2. Ka Hoʻonohonoho ʻana a me ke ʻAno Hana
ʻO ka soy, mai Glycine maxi, he kiʻekiʻe i ka protein a loaʻa iā ia nā isoflavones, me ka glycitein, equol, daidzein, a me genistein. ʻO kēia mau isoflavones, i kapa ʻia hoʻi he phytoestrogens, he hopena estrogenic paha i loko o ke kanaka.
3.8.3. Nā Hōʻike ʻEpekema
Loaʻa i nā pīni soya nā isoflavones he nui me nā pono anti-kahiko. Ma waena o nā hopena biologic ʻē aʻe, hōʻike ka glycitein i nā hopena antioxidant. Ua hōʻike nā fibroblasts dermal i mālama ʻia me ka glycitein i ka hoʻonui ʻia o ka hoʻonui ʻana o nā cell a me ka neʻe ʻana, hoʻonui ʻia ka synthesis o nā ʻano collagen I a me III, a hoʻemi ʻia ka MMP-1. Ma kahi noiʻi ʻokoʻa, ua hui pū ʻia ka soy extract me ka haematococcus extract (ʻo ka limu wai maʻemaʻe he kiʻekiʻe hoʻi i nā antioxidants), ka mea i hoʻohaʻahaʻa i ka MMP-1 mRNA a me ka hōʻike ʻana o ka protein. Ua hōʻike ʻo Daidzein, kahi isoflavone soy, i nā hopena anti-wrinkle, hoʻomālamalama ʻili, a me ka hydrating ʻili. Hiki iā Diadzein ke hana ma ka hoʻoulu ʻana i ka estrogen-receptor-β i loko o ka ʻili, e hopena ana i ka hoʻonui ʻia ʻana o ka hōʻike ʻana o nā antioxidants endogenous a me ka hoʻemi ʻana i ka hōʻike ʻana o nā mea transcription e alakaʻi ai i ka hoʻonui ʻana o keratinocyte a me ka neʻe ʻana. Ua hoʻonui ka isoflavonoid equol i loaʻa mai ka soy i ka collagen a me ka elastin a hoʻemi i nā MMP i ka moʻomeheu cell.
Ua hōʻike ʻia nā haʻawina murine in vivo hou i ka emi ʻana o ka make ʻana o nā cell i hoʻokomo ʻia e ka UVB a me ka emi ʻana o ka mānoanoa o ka epidermal i loko o nā cell ma hope o ka hoʻopili ʻana o nā isoflavone extracts ma ke ʻano topical. Ma kahi noiʻi hoʻāʻo o 30 mau wahine postmenopausal, ʻo ka lawelawe waha ʻana o ka isoflavone extract no ʻeono mahina i hopena i ka hoʻonui ʻia ʻana o ka mānoanoa o ka epidermal a me ka hoʻonui ʻia ʻana o ka collagen dermal e like me ke ana ʻia e nā biopsies ʻili ma nā wahi i pale ʻia e ka lā. Ma kahi noiʻi ʻokoʻa, ua kāohi nā isoflavones soy i hoʻomaʻemaʻe ʻia i ka make ʻana o keratinocyte i hoʻokomo ʻia e ka UV a ua hoʻemi i ka TEWL, ka mānoanoa o ka epidermal, a me ka erythema i ka ʻili ʻiole i hōʻike ʻia e ka UV.
Ua hoʻohālikelike ʻia kahi RCT makapō pālua o 30 mau wahine i piha i ka makahiki 45-55 i ka hoʻopili ʻana o ka estrogen a me ka genistein (soy isoflavone) i ka ʻili no 24 mau pule. ʻOiai ua loaʻa i ka hui e hoʻopili ana i ka estrogen i ka ʻili nā hopena maikaʻi loa, ua hōʻike nā hui ʻelua i ka hoʻonui ʻia ʻana o ke collagen maka ʻano I a me III e pili ana i nā biopsies ʻili o ka ʻili preauricular. Hiki i nā oligopeptides soy ke hoʻemi i ka helu erythema i ka ʻili i hōʻike ʻia e ka UVB (forearm) a hoʻemi i nā cell sunburnt a me nā cyclobutene pyrimidine dimers i nā cell foreskin irradiated UVB ex vivo. Ua hōʻike ʻia kahi hoʻokolohua lapaʻau 12-pule i hoʻomalu ʻia e ka kaʻa makapō pālua e pili ana i 65 mau kumuhana wahine me ka photodamage maka waena i kahi hoʻomaikaʻi ʻana i ka pigmentation mottled, blotchiness, dullness, fine lines, skin texture, a me ke kani ʻili i ka hoʻohālikelike ʻia me ke kaʻa. I ka hui pū ʻana, hiki i kēia mau mea ke hāʻawi i nā hopena anti-aging hiki, akā pono nā hoʻokolohua lapaʻau randomized ikaika aʻe e hōʻike pono i kona pono.
4. Kūkākūkā
ʻO nā huahana botanical, me nā mea i kūkākūkā ʻia ma ʻaneʻi, he mau hopena anti-aging paha. ʻO nā ʻano hana o nā botanicals anti-aging e komo pū me ka hiki ke hoʻopau i nā radical manuahi o nā antioxidants i hoʻopili ʻia ma luna, ka hoʻonui ʻana i ka pale ʻana i ka lā, ka hoʻonui ʻana i ka moisturization o ka ʻili, a me nā hopena he nui e alakaʻi ana i ka hoʻonui ʻana i ka hoʻokumu ʻana o ka collagen a i ʻole ka emi ʻana o ka haki ʻana o ka collagen. He haʻahaʻa kekahi o kēia mau hopena i ka hoʻohālikelike ʻia me nā lāʻau lapaʻau, akā ʻaʻole kēia e hōʻemi i ko lākou pono kūpono ke hoʻohana ʻia me nā hana ʻē aʻe e like me ka pale ʻana i ka lā, ka hoʻohana ʻana i nā sunscreens, ka moisturization i kēlā me kēia lā a me ka mālama kūpono ʻana o nā loea lapaʻau no nā maʻi ʻili e kū nei.
Eia kekahi, hāʻawi nā mea kanu i nā mea hana olaola ʻē aʻe no nā poʻe maʻi e makemake e hoʻohana wale i nā mea "kūlohelohe" ma ko lākou ʻili. ʻOiai ua loaʻa kēia mau mea i ke kūlohelohe, he mea nui e hoʻomaopopo i nā poʻe maʻi ʻaʻole kēia manaʻo he ʻaʻohe hopena maikaʻi ʻole o kēia mau mea, ʻo ka ʻoiaʻiʻo, ua ʻike ʻia he nui nā huahana botanical he kumu kūpono ia o ka dermatitis pili maʻi.
ʻOiai ʻaʻole pono nā huahana hoʻonani i ka pae like o nā hōʻike e hōʻoia i ka pono, he mea paʻakikī pinepine ke hoʻoholo inā he ʻoiaʻiʻo nā koi o nā hopena anti-aging. Eia nō naʻe, he nui nā mea kanu i helu ʻia ma ʻaneʻi i loaʻa nā hopena anti-aging, akā pono nā hoʻokolohua lapaʻau ikaika aʻe. ʻOiai he mea paʻakikī ke wānana pehea e pōmaikaʻi pololei ai kēia mau mea kanu i nā mea maʻi a me nā mea kūʻai aku i ka wā e hiki mai ana, he mea hiki loa ia no ka hapa nui o kēia mau mea kanu, e hoʻomau ʻia nā ʻano hana e hoʻokomo iā lākou ma ke ʻano he mau huahana mālama ʻili a inā mālama lākou i kahi palena palekana ākea, ʻae ʻia e ka mea kūʻai aku, a me ke kumukūʻai kūpono, e noho mau lākou i loko o nā hana mālama ʻili maʻamau, e hāʻawi ana i nā pono liʻiliʻi i ke olakino ʻili. Eia nō naʻe, no kahi helu palena o kēia mau mea kanu, hiki ke loaʻa kahi hopena nui aʻe i ka heluna kanaka ma ka hoʻoikaika ʻana i nā hōʻike o kā lākou hana olaola, ma o nā hoʻāʻo biomarker throughput kiʻekiʻe maʻamau a ma hope o ke kau ʻana i nā pahuhopu hoʻohiki nui loa i ka hoʻāʻo hoʻokolohua lapaʻau.
Ka manawa hoʻouna: Mei-11-2023
