I. Hoʻolauna
ʻO nā phospholipids kahi papa o nā lipids he mau ʻāpana koʻikoʻi o nā membrane cell. ʻO ko lākou ʻano kūikawā, i haku ʻia me kahi poʻo hydrophilic a me ʻelua huelo hydrophobic, e ʻae i nā phospholipids e hana i kahi ʻano bilayer, e lawelawe ana ma ke ʻano he pale e hoʻokaʻawale i nā mea o loko o ke kelepona mai ke kaiapuni waho. He mea nui kēia kuleana kūkulu no ka mālama ʻana i ka pono a me ka hana o nā kelepona i nā meaola ola āpau.
ʻO ka hōʻailona kelepona a me ke kamaʻilio ʻana he mau kaʻina hana koʻikoʻi e hiki ai i nā kelepona ke launa pū me kekahi a me ko lākou wahi noho, e ʻae ana i nā pane i hoʻonohonoho ʻia i nā ʻano stimuli like ʻole. Hiki i nā kelepona ke hoʻoponopono i ka ulu ʻana, ka hoʻomohala ʻana, a me nā hana physiological he nui ma o kēia mau kaʻina hana. Pili nā ala hōʻailona kelepona i ka hoʻoili ʻana o nā hōʻailona, e like me nā hormones a i ʻole neurotransmitters, i ʻike ʻia e nā mea loaʻa ma ka membrane kelepona, e hoʻoulu ana i kahi cascade o nā hanana e alakaʻi hope loa i kahi pane kelepona kikoʻī.
He mea koʻikoʻi ka hoʻomaopopo ʻana i ke kuleana o nā phospholipids i ka hōʻailona a me ke kamaʻilio ʻana o ke kelepona no ka wehe ʻana i nā paʻakikī o ke ʻano o ke kamaʻilio ʻana a me ka hoʻonohonoho ʻana o nā kelepona i kā lākou mau hana. He hopena koʻikoʻi kēia ʻike ma nā ʻano like ʻole, me ke olaola kelepona, ka pharmacology, a me ka hoʻomohala ʻana i nā lāʻau lapaʻau i kuhikuhi ʻia no nā maʻi a me nā maʻi he nui. Ma ka ʻimi ʻana i ka pilina paʻakikī ma waena o nā phospholipids a me ka hōʻailona kelepona, hiki iā mākou ke loaʻa ka ʻike i nā kaʻina hana kumu e hoʻomalu ana i ke ʻano a me ka hana o ke kelepona.
II. ʻAno o nā Phospholipids
A. Wehewehena o ke ʻano o ka Phospholipid:
He mau molekala amphipathic nā phospholipids, ʻo ia hoʻi, he mau ʻāpana hydrophilic (hoʻowalewale wai) a me hydrophobic (pale wai) ko lākou. ʻO ke ʻano kumu o ka phospholipid he molekala glycerol i hoʻopaʻa ʻia i ʻelua kaulahao waikawa momona a me kahi hui poʻo i loaʻa ka phosphate. ʻO nā huelo hydrophobic, i haku ʻia me nā kaulahao waikawa momona, e hana i loko o ka lipid bilayer, ʻoiai nā hui poʻo hydrophilic e launa pū me ka wai ma nā ʻili o loko a me waho o ka membrane. ʻO kēia hoʻonohonoho kū hoʻokahi e ʻae i nā phospholipids e hōʻuluʻulu ponoʻī i loko o kahi bilayer, me nā huelo hydrophobic i kuhikuhi ʻia i loko a me nā poʻo hydrophilic e kū pono ana i nā wahi wai i loko a ma waho o ke kelepona.
B. Ke kuleana o ka Phospholipid Bilayer i loko o ka Cell Membrane:
ʻO ka phospholipid bilayer kahi ʻāpana hoʻonohonoho koʻikoʻi o ka membrane cell, e hāʻawi ana i kahi pale semi-permeable e kāohi ana i ke kahe o nā mea i loko a i waho o ke kelepona. He mea nui kēia permeability koho no ka mālama ʻana i ke kaiapuni kūloko o ke kelepona a he mea nui ia no nā kaʻina hana e like me ka lawe ʻana i nā meaʻai, ka hoʻopau ʻana i nā ʻōpala, a me ka pale ʻana i nā mea ʻino. Ma waho aʻe o kona kuleana hoʻonohonoho, he kuleana koʻikoʻi nō hoʻi ka phospholipid bilayer i ka hōʻailona a me ke kamaʻilio ʻana o ke kelepona.
ʻO ke kumu hoʻohālike mosaic wai o ka membrane cell, i hāpai ʻia e Singer lāua ʻo Nicolson i ka makahiki 1972, e hōʻike ana i ke ʻano ikaika a me ka heterogeneous o ka membrane, me nā phospholipids e neʻe mau ana a me nā protein like ʻole i hoʻopuehu ʻia ma loko o ka lipid bilayer. He mea nui kēia ʻano hana ikaika i ka hoʻomaʻamaʻa ʻana i ka hōʻailona cell a me ke kamaʻilio ʻana. Hoʻokomo ʻia nā mea hoʻokipa, nā kahawai ion, a me nā protein hōʻailona ʻē aʻe i loko o ka phospholipid bilayer a he mea nui ia no ka ʻike ʻana i nā hōʻailona o waho a me ka hoʻouna ʻana iā lākou i loko o ke cell.
Eia kekahi, ʻo nā waiwai kino o nā phospholipids, e like me ko lākou kahe a me ka hiki ke hana i nā lipid rafts, e hoʻopili i ka hoʻonohonoho ʻana a me ka hana ʻana o nā protein membrane e pili ana i ka hōʻailona cell. Hoʻopili ka hana ikaika o nā phospholipids i ka localization a me ka hana o nā protein hōʻailona, a pēlā e hoʻopilikia ai i ke kikoʻī a me ka pono o nā ala hōʻailona.
ʻO ka hoʻomaopopo ʻana i ka pilina ma waena o nā phospholipids a me ke ʻano a me ka hana o ka membrane cell he hopena koʻikoʻi ia no nā kaʻina hana olaola he nui, me ka homeostasis cellular, ka ulu ʻana, a me nā maʻi. Ke hoʻomau nei ka hoʻohui ʻana o ka biology phospholipid me ka noiʻi hōʻailona cell e hōʻike i nā ʻike koʻikoʻi i loko o nā intricacies o ke kamaʻilio ʻana o ke kelepona a paʻa i ka hoʻohiki no ka hoʻomohala ʻana i nā hoʻolālā therapeutic hou.
III. Ke kuleana o nā Phospholipids i ka hōʻailona ʻana o ke kelepona
A. Nā Phospholipids ma ke ʻano he mau Molekula Hōʻailona
ʻO nā phospholipids, ma ke ʻano he mau ʻāpana koʻikoʻi o nā membrane cell, ua puka mai ma ke ʻano he mau molekala hōʻailona koʻikoʻi i ke kamaʻilio ʻana o ke kelepona. ʻO nā hui poʻo hydrophilic o nā phospholipids, ʻoiai nā mea i loaʻa nā inositol phosphates, e lawelawe ma ke ʻano he mau ʻelele lua koʻikoʻi i nā ala hōʻailona like ʻole. No ka laʻana, hana ʻo phosphatidylinositol 4,5-bisphosphate (PIP2) ma ke ʻano he molekala hōʻailona ma ka ʻoki ʻia ʻana i loko o ka inositol trisphosphate (IP3) a me diacylglycerol (DAG) i ka pane ʻana i nā stimuli extracellular. He kuleana koʻikoʻi kēia mau molekala hōʻailona i loaʻa mai ka lipid i ka hoʻoponopono ʻana i nā pae calcium intracellular a me ka hoʻoulu ʻana i ka protein kinase C, no laila e hoʻololi ana i nā kaʻina hana cellular like ʻole me ka hoʻonui ʻana o ke kelepona, ka hoʻokaʻawale ʻana, a me ka neʻe ʻana.
Eia kekahi, ua ʻike ʻia nā phospholipids e like me ka phosphatidic acid (PA) a me nā lysophospholipids he mau molekala hōʻailona e hoʻohuli pololei i nā pane cellular ma o nā pilina me nā pahuhopu protein kikoʻī. No ka laʻana, hana ʻo PA ma ke ʻano he mea hoʻoponopono koʻikoʻi i ka ulu ʻana o ke kelepona a me ka hoʻonui ʻana ma o ka hoʻoulu ʻana i nā protein hōʻailona, ʻoiai ʻo ka lysophosphatidic acid (LPA) e pili ana i ka hoʻoponopono ʻana i nā dynamics cytoskeletal, ke ola ʻana o ke kelepona, a me ka neʻe ʻana. Hōʻike kēia mau kuleana like ʻole o nā phospholipids i ko lākou koʻikoʻi i ka hoʻonohonoho ʻana i nā cascades hōʻailona paʻakikī i loko o nā cell.
B. Ke komo ʻana o nā Phospholipids i nā Ala Hoʻoili Hōʻailona
Ua hōʻike ʻia ke komo ʻana o nā phospholipids i nā ala transduction hōʻailona e ko lākou kuleana koʻikoʻi i ka hoʻololi ʻana i ka hana o nā mea loaʻa i hoʻopaʻa ʻia e ka membrane, ʻoiai nā mea loaʻa i hoʻopili ʻia me ka protein G (GPCRs). Ma hope o ka hoʻopaʻa ʻana o ka ligand i nā GPCRs, hoʻāla ʻia ka phospholipase C (PLC), e alakaʻi ana i ka hydrolysis o PIP2 a me ka hanauna o IP3 a me DAG. Hoʻāla ʻo IP3 i ka hoʻokuʻu ʻana o ka calcium mai nā hale kūʻai intracellular, ʻoiai ʻo DAG e hoʻāla i ka protein kinase C, a hiki i ka hoʻoponopono ʻana i ka hōʻike ʻana o ka gene, ka ulu ʻana o ke kelepona, a me ka hoʻoili synaptic.
Eia kekahi, ʻo nā phosphoinositides, kahi papa o nā phospholipids, e lawelawe ma ke ʻano he mau wahi hoʻopaʻa no nā protein hōʻailona e pili ana i nā ala like ʻole, me nā mea e hoʻoponopono ana i ka hoʻoili ʻana o ka membrane a me ka dynamics actin cytoskeleton. ʻO ka pilina ikaika ma waena o nā phosphoinositides a me kā lākou mau protein e launa pū ana e kōkua i ka hoʻoponopono spatial a me ka manawa o nā hanana hōʻailona, a pēlā e hoʻopili ai i nā pane cellular i nā stimuli extracellular.
ʻO ka hoʻokomo ʻana o nā phospholipids i nā ala hōʻailona cell a me nā ala transduction hōʻailona e hōʻike ana i ko lākou koʻikoʻi ma ke ʻano he mau mea hoʻoponopono koʻikoʻi o ka homeostasis cellular a me ka hana.
IV. Nā Phospholipids a me ke Kamaʻilio Intracellular
A. Nā Phospholipids i ka Hōʻailona Intracellular
ʻO nā phospholipids, kahi papa o nā lipids e loaʻa ana kahi hui phosphate, e pāʻani i nā kuleana koʻikoʻi i ka hōʻailona intracellular, e hoʻonohonoho ana i nā kaʻina hana cellular like ʻole ma o ko lākou komo ʻana i nā cascades hōʻailona. ʻO kahi laʻana koʻikoʻi ʻo phosphatidylinositol 4,5-bisphosphate (PIP2), kahi phospholipid i loaʻa i loko o ka membrane plasma. I ka pane ʻana i nā stimuli extracellular, ua ʻoki ʻia ʻo PIP2 i inositol trisphosphate (IP3) a me diacylglycerol (DAG) e ka enzyme phospholipase C (PLC). Hoʻoulu ka IP3 i ka hoʻokuʻu ʻana o ka calcium mai nā hale kūʻai intracellular, ʻoiai ʻo DAG e hoʻāla i ka protein kinase C, e hoʻoponopono hope ana i nā hana cellular like ʻole e like me ka hoʻonui ʻana o nā cell, ka hoʻokaʻawale ʻana, a me ka hoʻonohonoho hou ʻana o ka cytoskeletal.
Eia kekahi, ua ʻike ʻia nā phospholipids ʻē aʻe, me ka waikawa phosphatidic (PA) a me nā lysophospholipids, he mea koʻikoʻi i ka hōʻailona intracellular. Hāʻawi ʻo PA i ka hoʻoponopono ʻana i ka ulu ʻana o nā cell a me ka hoʻonui ʻana ma o ka hana ʻana ma ke ʻano he mea hoʻoulu o nā protein hōʻailona like ʻole. Ua ʻike ʻia ka waikawa Lysophosphatidic (LPA) no kona komo ʻana i ka modulation o ke ola ʻana o nā cell, ka neʻe ʻana, a me nā dynamics cytoskeletal. Hōʻike kēia mau ʻike i nā kuleana like ʻole a koʻikoʻi o nā phospholipids ma ke ʻano he mau molekala hōʻailona i loko o ke kelepona.
B. Ka Pilina ʻana o nā Phospholipids me nā Protein a me nā Receptors
Hoʻopili pū nā phospholipids me nā protein like ʻole a me nā mea loaʻa e hoʻololi i nā ala hōʻailona cellular. ʻO ka mea nui, ʻo nā phosphoinositides, kahi hui liʻiliʻi o nā phospholipids, e lawelawe ma ke ʻano he kahua no ka hoʻolimalima ʻana a me ka hoʻoulu ʻana i nā protein hōʻailona. No ka laʻana, hana ʻo phosphatidylinositol 3,4,5-trisphosphate (PIP3) ma ke ʻano he mea hoʻoponopono koʻikoʻi o ka ulu ʻana o nā cell a me ka hoʻonui ʻana ma o ka hoʻolimalima ʻana i nā protein e loaʻa ana nā kikowaena pleckstrin homology (PH) i ka membrane plasma, no laila e hoʻomaka ana i nā hanana hōʻailona ma lalo. Eia kekahi, ʻo ka hui ikaika o nā phospholipids me nā protein hōʻailona a me nā mea loaʻa e ʻae i ka kaohi spatiotemporal pololei o nā hanana hōʻailona i loko o ke kelepona.
ʻO nā pilina multifaceted o nā phospholipids me nā protein a me nā mea loaʻa e hōʻike ana i kā lākou kuleana koʻikoʻi i ka modulation o nā ala hōʻailona intracellular, a i ka hopena e hāʻawi ana i ka hoʻoponopono ʻana i nā hana cellular.
V. Ka Hoʻoponopono ʻana o nā Phospholipids i ka Hōʻailona Kelepona
A. Nā ʻenzyme a me nā ala e pili ana i ka metabolism phospholipid
Hoʻoponopono ʻia nā phospholipids ma o kahi pūnaewele paʻakikī o nā enzymes a me nā ala, e hoʻohuli ana i ko lākou nui a me ka hana i ka hōʻailona cell. ʻO kekahi ala e pili ana i ka synthesis a me ka hoʻololi ʻana o phosphatidylinositol (PI) a me kāna mau derivatives phosphorylated, i ʻike ʻia ʻo phosphoinositides. ʻO Phosphatidylinositol 4-kinases a me phosphatidylinositol 4-phosphate 5-kinases he mau enzymes e hoʻoulu ai i ka phosphorylation o PI ma nā kūlana D4 a me D5, e hana ana i ka phosphatidylinositol 4-phosphate (PI4P) a me phosphatidylinositol 4,5-bisphosphate (PIP2), kēlā me kēia. I ka ʻaoʻao ʻē aʻe, ʻo nā phosphatases, e like me ka phosphatase a me ka tensin homolog (PTEN), dephosphorylate phosphoinositides, e hoʻoponopono ana i ko lākou mau pae a me ka hopena ma ka hōʻailona cellular.
Eia kekahi, ʻo ka synthesis de novo o nā phospholipids, ʻoiai ka waikawa phosphatidic (PA), ua hoʻopili ʻia e nā enzymes e like me phospholipase D a me diacylglycerol kinase, ʻoiai ua hoʻoulu ʻia ko lākou degradation e nā phospholipases, me ka phospholipase A2 a me ka phospholipase C. Hoʻomalu pū kēia mau hana enzymatic i nā pae o nā mea hoʻopili lipid bioactive, e hoʻopilikia ana i nā kaʻina hana hōʻailona cell like ʻole a me ka hāʻawi ʻana i ka mālama ʻana i ka homeostasis cellular.
B. Ka hopena o ka hoʻoponopono ʻana o Phospholipid i nā kaʻina hana hōʻailona kelepona
Hoʻopilikia nui ka hoʻoponopono ʻana o nā phospholipids i nā kaʻina hana hōʻailona cell ma o ka hoʻololi ʻana i nā hana o nā molekala hōʻailona koʻikoʻi a me nā ala. No ka laʻana, ʻo ka hoʻololi ʻana o PIP2 e ka phospholipase C e hoʻopuka i ka inositol trisphosphate (IP3) a me ka diacylglycerol (DAG), e alakaʻi ana i ka hoʻokuʻu ʻia ʻana o ka calcium intracellular a me ka hoʻāla ʻana o ka protein kinase C, kēlā me kēia. Hoʻopilikia kēia cascade hōʻailona i nā pane cellular e like me ka neurotransmission, ka ʻūlū ʻana o ka ʻiʻo, a me ka hoʻāla ʻana o nā cell immune.
Eia kekahi, ʻo nā loli i nā pae o phosphoinositides e hoʻopilikia i ka hoʻolimalima ʻana a me ka hoʻāla ʻana o nā protein effector e loaʻa ana nā ʻāpana lipid-binding, e hoʻopilikia ana i nā kaʻina hana e like me ka endocytosis, cytoskeletal dynamics, a me ka neʻe ʻana o nā cell. Eia kekahi, ʻo ka hoʻoponopono ʻana o nā pae PA e nā phospholipases a me nā phosphatases e hoʻopilikia i ka membrane trafficking, ka ulu ʻana o nā cell, a me nā ala hōʻailona lipid.
ʻO ka pilina ma waena o ka metabolism phospholipid a me ka hōʻailona cell e hōʻike ana i ke koʻikoʻi o ka hoʻoponopono phospholipid i ka mālama ʻana i ka hana cellular a me ka pane ʻana i nā stimuli extracellular.
VI. Hopena
A. Hōʻuluʻulu Manaʻo o nā Kuleana Koʻikoʻi o nā Phospholipids i ka Hōʻailona Kelepona a me ke Kamaʻilio ʻana
I ka hōʻuluʻulu manaʻo, hoʻokani nā phospholipids i nā kuleana koʻikoʻi i ka hoʻonohonoho ʻana i nā kaʻina hana hōʻailona cell a me ke kamaʻilio ʻana i loko o nā ʻōnaehana olaola. ʻO ko lākou ʻano like ʻole o ke ʻano a me ka hana e hiki ai iā lākou ke lawelawe ma ke ʻano he mau mea hoʻoponopono versatile o nā pane cellular, me nā kuleana koʻikoʻi e like me:
Hoʻonohonoho Membrane:
Hoʻokumu nā phospholipids i nā poloka kūkulu kumu o nā membrane cellular, e hoʻokumu ana i ke ʻano hana no ka hoʻokaʻawale ʻana o nā keʻena cellular a me ka localization o nā protein hōʻailona. ʻO ko lākou hiki ke hana i nā microdomains lipid, e like me nā lipid rafts, e hoʻohuli i ka hoʻonohonoho spatial o nā complexes hōʻailona a me kā lākou mau pilina, e hoʻopilikia ana i ka specificity signaling a me ka pono.
Ka Hoʻoili Hōʻailona:
Hana nā phospholipids ma ke ʻano he mau mea waena koʻikoʻi i ka hoʻololi ʻana o nā hōʻailona extracellular i nā pane intracellular. Hana nā phosphoinositides ma ke ʻano he mau mole hōʻailona, e hoʻololi ana i nā hana o nā protein effector like ʻole, ʻoiai ʻo nā waikawa momona manuahi a me nā lysophospholipids e hana ma ke ʻano he mau ʻelele lua, e hoʻohuli ana i ka hoʻoulu ʻana o nā cascades hōʻailona a me ka hōʻike ʻana o ka gene.
Hoʻololi Hōʻailona Kelepona:
Hāʻawi nā phospholipids i ka hoʻoponopono ʻana i nā ala hōʻailona like ʻole, e hoʻokō ana i ka mana ma luna o nā kaʻina hana e like me ka hoʻonui ʻana o nā cell, ka hoʻokaʻawale ʻana, ka apoptosis, a me nā pane pale. ʻO kā lākou komo ʻana i ka hana ʻana o nā mea hoʻopili lipid bioactive, me nā eicosanoids a me nā sphingolipids, e hōʻike hou aku i ko lākou hopena ma nā pūnaewele hōʻailona inflammatory, metabolic, a me apoptotic.
Kamaʻilio ma waena o nā kelepona:
Hoʻokomo pū nā phospholipids i ka kamaʻilio intercellular ma o ka hoʻokuʻu ʻia ʻana o nā mea hoʻopili lipid, e like me nā prostaglandins a me nā leukotrienes, ka mea e hoʻololi i nā hana o nā cell a me nā ʻiʻo e pili ana, e hoʻoponopono ana i ka mumū, ka ʻike ʻeha, a me ka hana vascular.
ʻO nā hāʻawina multifaceted o nā phospholipids i ka hōʻailona cell a me ke kamaʻilio e hōʻike ana i ko lākou pono i ka mālama ʻana i ka homeostasis cellular a me ka hoʻonohonoho ʻana i nā pane physiological.
B. Nā Kuhikuhi no ka Noiʻi ʻana ma nā Phospholipids i ka Hōʻailona Kelepona
I ka hoʻomau ʻia ʻana o ka wehe ʻia ʻana o nā kuleana paʻakikī o nā phospholipids i ka hōʻailona cell, ua puka mai kekahi mau ala hoihoi no ka noiʻi e hiki mai ana, me:
Nā ʻAno Hana Interdisciplinary:
ʻO ka hoʻohui ʻana o nā ʻano hana loiloi holomua, e like me lipidomics, me ka biology molecular a me ke kelepona e hoʻonui i ko mākou ʻike i ka dynamics spatial a me ka temporal o phospholipids i nā kaʻina hana hōʻailona. ʻO ka ʻimi ʻana i ka crosstalk ma waena o ka metabolism lipid, ka membrane trafficking, a me ka hōʻailona kelepona e hōʻike i nā ʻano hana hoʻoponopono hou a me nā pahuhopu therapeutic.
Nā Manaʻo o ka Biology ʻōnaehana:
ʻO ka hoʻohana ʻana i nā ʻano hana biology ʻōnaehana, me ke kumu hoʻohālike makemakika a me ka nānā ʻana i ka pūnaewele, e hiki ai ke wehewehe i ka hopena honua o nā phospholipids ma nā pūnaewele hōʻailona kelepona. ʻO ke kumu hoʻohālike i nā pilina ma waena o nā phospholipids, nā enzymes, a me nā mea hoʻokō hōʻailona e wehewehe i nā waiwai e kū mai ana a me nā ʻano hana manaʻo e hoʻomalu ana i ka hoʻoponopono ʻana i ke ala hōʻailona.
Nā hopena lapaʻau:
ʻO ka noiʻi ʻana i ka dysregulation o nā phospholipids i nā maʻi, e like me ke kanesa, nā maʻi neurodegenerative, a me nā metabolic syndromes, hāʻawi i kahi manawa kūpono e hoʻomohala i nā therapies i kuhikuhi ʻia. ʻO ka hoʻomaopopo ʻana i nā kuleana o nā phospholipids i ka holomua o ka maʻi a me ka ʻike ʻana i nā hoʻolālā hou e hoʻololi i kā lākou mau hana e paʻa ana i ka hoʻohiki no nā ʻano lāʻau lapaʻau pololei.
I ka hopena, ʻo ka ʻike e hoʻonui mau nei i nā phospholipids a me ko lākou komo paʻakikī i ka hōʻailona cellular a me ke kamaʻilio ʻana e hōʻike ana i kahi palena hoihoi no ka hoʻomau ʻana i ka ʻimi a me ka hopena unuhi kūpono i nā ʻano like ʻole o ka noiʻi biomedical.
Nā Kuhikuhi:
ʻO Balla, T. (2013). Phosphoinositides: nā lipids liʻiliʻi me ka hopena nui ma ka hoʻoponopono ʻana o nā cell. Physiological Reviews, 93(3), 1019-1137.
ʻO Di Paolo, G., & De Camilli, P. (2006). Nā Phosphoinositides i ka hoʻoponopono ʻana o nā cell a me nā dynamics membrane. Nature, 443(7112), 651-657.
Kooijman, EE, & Testerink, C. (2010). ʻAkika Phosphatidic: kahi mea pāʻani koʻikoʻi e kū mai ana i ka hōʻailona kelepona. Nā ʻAno i ka ʻEpekema Mea kanu, 15(6), 213-220.
Hilgemann, DW, & Ball, R. (1996). Ka hoʻoponopono ʻana o nā kahawai potassium Na(+), H(+)-exchange a me K(ATP) cardiac e PIP2. ʻEpekema, 273(5277), 956-959.
ʻO Kaksonen, M., & Roux, A. (2018). Nā ʻano hana o ka endocytosis i hoʻopili ʻia e clathrin. Nature Reviews Molecular Cell Biology, 19(5), 313-326.
ʻO Balla, T. (2013). Phosphoinositides: nā lipids liʻiliʻi me ka hopena nui ma ka hoʻoponopono ʻana o nā cell. Physiological Reviews, 93(3), 1019-1137.
ʻO Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., & Walter, P. (2014). ʻO ke olaola molekala o ke kelepona (6th ed.). ʻEpekema Garland.
ʻO Simons, K., & Vaz, WL (2004). Nā ʻōnaehana hoʻohālike, nā lipid rafts, a me nā membrane cell. Ka Nānā Makahiki o Biophysics a me ke ʻAno Biomolecular, 33, 269-295.
Ka manawa hoʻouna: Dec-29-2023
