I. Hoolauna
Phospholipidshe mau ʻāpana koʻikoʻi o nā membrane biological a pāʻani i nā kuleana koʻikoʻi i nā kaʻina hana physiological. ʻO ka hoʻomaopopo ʻana i kā lākou hana a me ka hana he mea nui ia e hoʻomaopopo i ka paʻakikī o ka cellular a me ka molecular biology, a me ko lākou koʻikoʻi i ke olakino kanaka a me nā maʻi. Ke manaʻo nei kēia ʻike kikoʻī e ʻimi i ke ʻano paʻakikī o nā phospholipids, e ʻimi ana i kā lākou wehewehe a me ka hoʻolālā ʻana, a me ka hōʻike ʻana i ke koʻikoʻi o ke aʻo ʻana i kēia mau mole.
A. Ka wehewehe a me ke ano o ka Phospholipids
ʻO Phospholipids kahi papa o nā lipid i loaʻa i ʻelua mau kaulahao momona momona, kahi hui phosphate, a me kahi iwi kuamoʻo glycerol. ʻO ke ʻano kūʻokoʻa o nā phospholipids hiki iā lākou ke hana i ka lipid bilayer, ke kumu o nā membrane cell, me nā huelo hydrophobic e kū pono ana i loko a me nā poʻo hydrophilic e kū ana i waho. Hāʻawi kēia hoʻonohonoho i kahi pale ikaika e hoʻoponopono i ka neʻe ʻana o nā mea i loko a i waho o ke kelepona, ʻoiai e hoʻopili ana i nā kaʻina kelepona like ʻole e like me ka hōʻailona a me ka lawe ʻana.
B. Pono o ke aʻo ʻana i nā Phospholipids
He mea koʻikoʻi ke aʻo ʻana i nā phospholipids no nā kumu he nui. ʻO ka mea mua, pili lākou i ka hoʻolālā a me ka hana o nā membrane cell, e hoʻopili ana i ka fluidity membrane, permeability, a me ke kūpaʻa. He mea nui ka hoʻomaopopo ʻana i nā waiwai o ka phospholipids no ka wehe ʻana i nā mīkini i lalo o nā kaʻina cellular e like me ka endocytosis, exocytosis, a me ka transduction hōʻailona.
Eia kekahi, he koʻikoʻi ko ka phospholipids i ke olakino kanaka, e pili ana i nā kūlana e like me ka maʻi puʻuwai, nā maʻi neurodegenerative, a me nā metabolic syndromes. Hiki i ka noiʻi ʻana i nā phospholipids ke hāʻawi i nā ʻike i ka hoʻomohala ʻana i nā hoʻolālā therapeutic novel a me nā hana meaʻai e kuhikuhi ana i kēia mau pilikia olakino.
Eia kekahi, ʻo ka hoʻohana ʻana i ka ʻoihana a me ka ʻoihana o phospholipids i nā wahi e like me ka lāʻau lapaʻau, nutraceuticals, a me ka biotechnology e hōʻike ana i ke koʻikoʻi o ka holomua ʻana i kā mākou ʻike ma kēia kahua. ʻO ka hoʻomaopopo ʻana i nā kuleana like ʻole a me nā waiwai o ka phospholipids hiki ke alakaʻi i ka hoʻomohala ʻana i nā huahana hou a me nā ʻenehana me nā hopena ākea no ka pono o ke kanaka a me ka holomua ʻenehana.
I ka hōʻuluʻulu ʻana, pono ke aʻo ʻana i nā phospholipids no ka wehe ʻana i ka ʻepekema paʻakikī ma hope o ka hoʻolālā cellular a me ka hana, e ʻimi ana i ko lākou hopena i ke olakino kanaka, a me ka hoʻohana ʻana i ko lākou hiki i nā noi ʻoihana like ʻole. Ke manaʻo nei kēia hiʻohiʻona piha e hoʻomālamalama i ke ʻano multifaceted o phospholipids a me ko lākou koʻikoʻi i loko o ke ʻano o ka noiʻi biological, olakino kanaka, a me ka ʻenehana hou.
II. Nā hana olaola o Phospholipids
ʻO Phospholipids, kahi mea koʻikoʻi o nā membrane cell, pāʻani i nā hana like ʻole i ka mālama ʻana i ke ʻano o ka cellular a me ka hana, a me ka hopena i nā kaʻina hana physiological. ʻO ka hoʻomaopopo ʻana i nā hana olaola o nā phospholipids e hāʻawi i ka ʻike i ko lākou koʻikoʻi i ke olakino kanaka a me nā maʻi.
A. Ke kuleana ma ke kūkulu ʻana a me ka hana o ka cell membrane
ʻO ka hana olaola mua o ka phospholipids ʻo kā lākou hāʻawi ʻana i ka hana a me ka hana o nā membrane cell. Hoʻokumu ka Phospholipids i ka lipid bilayer, ke ʻano kumu o nā membrane cell, ma ka hoʻonohonoho ʻana iā lākou iho me ko lākou huelo hydrophobic i loko a me nā poʻo hydrophilic i waho. Hoʻokumu kēia ʻano i kahi membrane semipermeable e hoʻoponopono ai i ka hele ʻana o nā mea i loko a i waho o ke kelepona, a laila mālama ʻia ka homeostasis cellular a hoʻomaʻamaʻa i nā hana koʻikoʻi e like me ka lawe ʻana i nā meaʻai, hoʻopau ʻōpala, a me ka hōʻailona cell.
B. Ka hōʻailona a me ke kamaʻilio ʻana ma nā Pūnaewele
Hoʻohana ʻia ʻo Phospholipids ma ke ʻano koʻikoʻi o nā ala hōʻailona a me ke kamaʻilio cell-to-cell. ʻO kekahi mau phospholipids, e like me ka phosphatidylinositol, e hana ma ke ʻano he mea mua no ka hōʻailona ʻana i nā molekele (e laʻa, inositol trisphosphate a me diacylglycerol) e hoʻoponopono i nā kaʻina cellular koʻikoʻi, me ka ulu ʻana o nā cell, ka ʻokoʻa, a me ka apoptosis. Hoʻokani kēia mau molekala hōʻailona i nā kuleana koʻikoʻi i loko o nā ʻano hōʻailona hōʻailona intracellular a intercellular, e hoʻohuli ana i nā pane physiological like ʻole a me nā ʻano kelepona.
C. Hāʻawi i ke olakino lolo a me ka hana noʻonoʻo
ʻO Phospholipids, ʻoi aku ka phosphatidylcholine, a me ka phosphatidylserine, he nui i ka lolo a he mea nui ia no ka mālama ʻana i kona ʻano a me kāna hana. Hāʻawi ka Phospholipids i ka hoʻokumu ʻana a me ka paʻa ʻana o nā membrane neuronal, kōkua i ka hoʻokuʻu ʻana a me ka uptake o ka neurotransmitter, a komo i ka synaptic plasticity, he mea koʻikoʻi no ke aʻo ʻana a me ka hoʻomanaʻo. Eia kekahi, hoʻokani nā phospholipids i nā hana neuroprotective a ua hoʻopili ʻia i ka hoʻoponopono ʻana i ka emi ʻana o ka cognitive e pili ana i ka ʻelemakule a me nā maʻi neurological.
D. Ka hopena i ke ola o ka naʻau a me ka hana naʻau
Ua hōʻike ʻo Phospholipids i nā hopena koʻikoʻi i ke olakino o ka naʻau a me ka hana cardiovascular. Hoʻopili lākou i ka hana a me ka hana o nā lipoproteins, e lawe ana i ka cholesterol a me nā lipids ʻē aʻe i ke kahe koko. Hāʻawi ka Phospholipids i loko o nā lipoproteins i ko lākou kūpaʻa a me ka hana, ka hopena o ka lipid metabolism a me ka homeostasis cholesterol. Hoʻohui ʻia, ua aʻo ʻia nā phospholipids no ko lākou hiki ke hoʻololi i nā profile lipid koko a hōʻemi i ka hopena o nā maʻi cardiovascular, e hōʻike ana i kā lākou hopena therapeutic i ka mālama ʻana i ke olakino naʻau.
E. Hoʻokomo i ka Lipid Metabolism a me Energy Production
ʻO Phospholipids ka mea hoʻohui i ka lipid metabolism a me ka hana ikehu. Hoʻopili lākou i ka synthesis a me ka haki ʻana o nā lipids, me ka triglycerides a me ka cholesterol, a ke pāʻani nei i nā kuleana koʻikoʻi i ka lawe ʻana a me ka mālama ʻana i nā lipid. Hāʻawi pū ka Phospholipids i ka hana mitochondrial a me ka hana ikehu ma o ko lākou komo ʻana i ka phosphorylation oxidative a me ke kaulahao lawe electron, e hōʻike ana i ko lākou koʻikoʻi i ka metabolism ikehu cellular.
I ka hōʻuluʻuluʻana, he nui nā hana olaola o ka phospholipids a hoʻopili i kā lākou mau kuleana i ka hoʻolālā a me ka hana o ka membrane cell, ka hōʻailona a me ke kamaʻilio ʻana i loko o nā cell, hāʻawi i ke olakino lolo a me ka hana cognitive, ka hopena i ke olakino naʻau a me ka hana cardiovascular, a me ke komo ʻana i ka lipid metabolism a me ka ikehu. hana ʻana. Hāʻawi kēia ʻike kikoʻī i kahi ʻike hohonu o nā hana olaola like ʻole o ka phospholipids a me kā lākou hopena i ke olakino a me ka maikaʻi o ke kanaka.
III. Nā Pōmaikaʻi Ola o Phospholipids
ʻO Phospholipids nā mea koʻikoʻi o nā membrane cell me nā kuleana like ʻole i ke olakino kanaka. ʻO ka hoʻomaopopo ʻana i nā pono olakino o ka phospholipids hiki ke hoʻomālamalama i kā lākou pono therapeutic a me nā noi meaʻai.
Nā hopena ma nā pae Cholesterol
He kuleana koʻikoʻi ka Phospholipids i ka metabolism lipid a me ka lawe ʻana, e hoʻopilikia pololei i nā pae cholesterol i ke kino. Ua hōʻike ka noiʻi e hiki i nā phospholipids ke hoʻololi i ka metabolism cholesterol ma o ka hoʻopili ʻana i ka synthesis, absorption, a me ka excretion o ka cholesterol. Ua hōʻike ʻia ʻo Phospholipids e kōkua i ka emulsification a me ka solubilization o nā momona meaʻai, no laila e hoʻomaʻamaʻa i ka absorption o ka cholesterol i loko o ka ʻōpū. Hoʻohui ʻia, komo nā phospholipids i ka hoʻokumu ʻana i nā lipoproteins kiʻekiʻe kiʻekiʻe (HDL), i ʻike ʻia no kā lākou kuleana i ka lawe ʻana i ka cholesterol keu mai ke kahe koko, no laila e hōʻemi i ka hopena o ka atherosclerosis a me nā maʻi cardiovascular. Hōʻike nā hōʻike e hiki i nā phospholipids ke hoʻomaikaʻi i nā profile lipid a kōkua i ka mālama ʻana i nā pae cholesterol olakino i ke kino.
Nā waiwai Antioxidative
Hōʻike nā Phospholipids i nā waiwai antioxidative e kōkua i kā lākou hopena maikaʻi i ke olakino. Ma ke ʻano he ʻāpana koʻikoʻi o nā membrane cellular, hiki i nā phospholipids ke hōʻino i ka oxidative e nā radical manuahi a me nā ʻano oxygen reactive. Eia nō naʻe, loaʻa i nā phospholipids ka mana antioxidative inherent, e hana ana ma ke ʻano he scavengers o nā radical manuahi a pale i nā cell mai ke kaumaha oxidative. Ua hōʻike nā haʻawina e hiki i nā phospholipids kikoʻī, e like me ka phosphatidylcholine a me ka phosphatidylethanolamine, hiki ke hoʻēmi pono i ka pōʻino oxidative a pale i ka lipid peroxidation. Eia kekahi, ua hoʻopili ʻia nā phospholipids i ka hoʻomaikaʻi ʻana i ka ʻōnaehana pale antioxidant i loko o nā cell, a laila e hana ana i kahi mana pale i ka pōʻino oxidative a me nā pathologies pili.
ʻO nā hoʻohana lāʻau lapaʻau kūpono a me nā meaʻai
ʻO nā pono olakino kūʻokoʻa o ka phospholipids ua hoʻoulu i ka hoihoi i kā lākou pono therapeutic a me nā noi meaʻai. Ke ʻimi ʻia nei nā lāʻau lapaʻau phospholipid no ko lākou hiki ke mālama i nā maʻi pili lipid, e like me ka hypercholesterolemia a me ka dyslipidemia. Eia kekahi, ua hōʻike nā phospholipids i ka ʻōlelo hoʻohiki i ka hoʻolaha ʻana i ke olakino ate a me ke kākoʻo ʻana i ka hana o ka ate, ʻoiai ma nā kūlana e pili ana i ka metabolism lipid hepatic a me ke kaumaha oxidative. Ua ʻike ʻia nā noi meaʻai o nā phospholipids ma ke ʻano o nā meaʻai hana a me nā mea hoʻohui meaʻai, kahi e hoʻomohala ʻia ai nā formulations waiwai phospholipid e hoʻomaikaʻi i ka assimilation lipid, hoʻoikaika i ke olakino cardiovascular, a kākoʻo i ka maikaʻi holoʻokoʻa.
I ka hopena, ʻo nā pono olakino o ka phospholipids e hoʻopili i kā lākou hopena i nā pae cholesterol, nā waiwai antioxidative, a me kā lākou hiki ke hoʻohana i ka therapeutic a me ka meaʻai. ʻO ka hoʻomaopopo ʻana i nā kuleana multifaceted o phospholipids i ka mālama ʻana i ka homeostasis physiological a me ka hoʻēmi ʻana i ka maʻi maʻi e hāʻawi i nā ʻike waiwai i ko lākou koʻikoʻi i ka hoʻolaha ʻana i ke olakino a me ka maikaʻi o ke kanaka.
IV. Nā kumu o Phospholipids
ʻO Phospholipids, ʻo ia nā ʻāpana lipid koʻikoʻi o nā membrane cellular, he mea nui ia no ka mālama ʻana i ka kūpaʻa a me ka hana o nā cell. ʻO ka hoʻomaopopo ʻana i nā kumu o phospholipids ka mea nui i ka mahalo i ko lākou koʻikoʻi i ka meaʻai a me nā noi ʻoihana.
A. Na Puna Mea ai
Nā Puna Meaʻai: Hiki ke loaʻa nā Phospholipids mai nā kumu meaʻai like ʻole, me kekahi o nā kumu waiwai ʻoi aku ka hua manu, nā ʻiʻo okana, a me ka soya. He nui loa nā yolks i loko o ka phosphatidylcholine, kahi ʻano phospholipid, aʻo ka soybeans ka phosphatidylserine a me ka phosphatidylinositol. ʻO nā kumu meaʻai ʻē aʻe o ka phospholipids e pili ana i nā huahana waiu, nā pīni, a me nā hua sunflower.
Koʻikoʻi koʻikoʻi: Pono nā phospholipid meaʻai no ka meaʻai kanaka a pāʻani i nā kuleana koʻikoʻi i nā kaʻina physiological like ʻole. I ka manawa e ʻai ʻia ai, ʻeli ʻia nā phospholipids a komo i loko o ka ʻōpū liʻiliʻi, kahi e lilo ai lākou i mau poloka no nā membrane cell o ke kino a kōkua i ka hoʻokumu ʻana a me ka hana o nā mea lipoprotein e lawe ana i ka cholesterol a me nā triglycerides.
Nā Manaʻo Ola: Ua hōʻike ʻia ka noiʻi e loaʻa paha i nā phospholipid meaʻai nā pono olakino, me ka hoʻomaikaʻi ʻana i ka hana o ka ate, ke kākoʻo ʻana i ke olakino lolo, a me ke kōkua ʻana i ke olakino cardiovascular. Eia kekahi, ʻo nā phospholipids i loaʻa mai nā kumu kai, e like me ka ʻaila krill, ua loaʻa i ka nānā ʻana no kā lākou mau waiwai anti-inflammatory a me antioxidant.
B. Nā Punawai Hana Hana a Lapaʻau
ʻO ka ʻOihana Hana: Loaʻa ʻia nā Phospholipids mai nā kumu ʻoihana, kahi i lawe ʻia mai nā mea kūlohelohe e like me ka soybeans, nā hua sunflower, a me nā rapeseeds. Hoʻopili ʻia kēia mau phospholipids a hoʻohana ʻia i nā noi ʻoihana like ʻole, me ka hana ʻana i nā emulsifiers, stabilizers, a me nā mea encapsulation no ka meaʻai, lāʻau lapaʻau, a me nā ʻoihana hoʻonaninani.
Nā noi lāʻau lapaʻau: He kuleana koʻikoʻi ka Phospholipids i ka ʻoihana lāʻau lapaʻau, ʻoi aku hoʻi i nā ʻōnaehana lawe lāʻau. Hoʻohana ʻia lākou e like me nā excipients i ka hoʻokumu ʻana i nā ʻōnaehana hāʻawi lāʻau lipid-based e hoʻomaikaʻi i ka bioavailability, kūpaʻa, a me ka huli ʻana o nā pūhui lāʻau. Hoʻohui ʻia, ua ʻimi ʻia nā phospholipids no ko lākou hiki ke hoʻomohala i nā mea lawe lāʻau lapaʻau hou no ka hāʻawi ʻia ʻana a me ka hoʻokuʻu mau ʻana o nā therapeutics.
Mea koʻikoʻi i ka ʻoihana: ʻO nā noi ʻoihana o nā phospholipids e hoʻonui i nā lāʻau lapaʻau e hoʻokomo i kā lākou hoʻohana ʻana i ka hana ʻana i ka meaʻai, kahi e lawelawe ai lākou ma ke ʻano he emulsifiers a me nā stabilizers i nā meaʻai like ʻole. Hoʻohana pū ʻia nā Phospholipids i ka hana ʻana i ka mālama pilikino a me nā huahana cosmetic, kahi e hāʻawi ai lākou i ka paʻa a me ka hana o nā mea hana e like me nā creams, lotions, a me nā liposomes.
I ka hopena, hoʻokumu ʻia nā phospholipids mai nā kumu meaʻai a me nā kumu ʻoihana, e pāʻani ana i nā kuleana koʻikoʻi i ka meaʻai kanaka, ke olakino, a me nā kaʻina hana ʻenehana. ʻO ka hoʻomaopopo ʻana i nā kumu like ʻole a me nā noi o phospholipids he mea nui ia e mahalo i ko lākou koʻikoʻi i ka meaʻai, olakino, a me ka ʻoihana.
V. Imi a me na noi
A. Nā ʻano noiʻi o kēia manawa ma Phopholipid
ʻEpekema ʻO ka noiʻi ʻana i kēia manawa i ka ʻepekema phospholipid e hoʻopili ana i kahi ākea o nā kumuhana e pili ana i ka hoʻomaopopo ʻana i ke ʻano, hana, a me nā kuleana o nā phospholipids i nā ʻano hana olaola like ʻole. ʻO nā ʻano hou e pili ana i ka noiʻi ʻana i nā kuleana kikoʻī a nā papa like ʻole o ka phospholipids e pāʻani ai i ka hōʻailona cell, membrane dynamics, a me ka lipid metabolism. Eia kekahi, nui ka hoihoi i ka hoʻomaopopo ʻana pehea e hiki ai i ka hoʻololi ʻana i ka haku mele phospholipid ke hoʻopilikia i ka physiology cellular a me ka organism, a me ka hoʻomohala ʻana i nā ʻenehana analytical hou no ke aʻo ʻana i nā phospholipids ma ka pae cellular a me ka molecular.
B. ʻOihana a me nā lāʻau lapaʻau
Ua loaʻa i nā Phospholipids nā noi ʻoihana a me nā lāʻau lapaʻau ma muli o kā lākou mau waiwai kino a me nā kemika. I ka ʻoihana ʻoihana, hoʻohana ʻia nā phospholipids e like me nā emulsifiers, stabilizers, a me nā mea encapsulating i loko o ka ʻoihana meaʻai, cosmetic, a me nā ʻoihana mālama pilikino. I loko o nā lāʻau lapaʻau, hoʻohana nui ʻia nā phospholipids i nā ʻōnaehana lawe lāʻau, me nā liposomes a me nā lipid-based formulations, e hoʻonui i ka solubility a me ka bioavailability o nā lāʻau lapaʻau. ʻO ka hoʻohana ʻana i nā phospholipids i kēia mau noi ua hoʻonui nui i ko lākou hopena i nā ʻoihana like ʻole.
C. Nā kuhikuhi a me nā pilikia i ka wā e hiki mai ana ma ka noiʻi Phopholipid
ʻO ka wā e hiki mai ana o ka noiʻi phospholipid e paʻa i ka ʻōlelo hoʻohiki nui, me nā kuhikuhi kūpono e pili ana i ka hoʻomohala ʻana i nā mea i hoʻokumu ʻia i ka phospholipid no nā noi biotechnological a me nanotechnological, a me ka ʻimi ʻana i nā phospholipids ma ke ʻano he mau pahuhopu no ka therapeutic interventions. E hoʻopili nā pilikia i ka hoʻoponopono ʻana i nā pilikia e pili ana i ka scalability, reproducibility, a me ka uku-pono o nā huahana phospholipid-based. Eia kekahi, ʻo ka hoʻomaopopo ʻana i ka pilina paʻakikī ma waena o nā phospholipids a me nā ʻāpana cellular ʻē aʻe, a me kā lākou kuleana i nā kaʻina maʻi, he wahi koʻikoʻi ia o ka hoʻomau ʻana.
D.Phospholipid LiposomalNā huahana Serial
ʻO nā huahana liposomal Phospholipid kahi wahi koʻikoʻi o ka nānā ʻana i nā noi lāʻau. ʻO nā liposomes, ʻo ia nā vesicles spherical i haku ʻia me nā bilayers phospholipid, ua aʻo nui ʻia e like me nā ʻōnaehana lawe lāʻau. Hāʻawi kēia mau huahana i nā pōmaikaʻi e like me ka hiki ke hoʻopili i nā lāʻau hydrophobic a me hydrophilic, e hoʻopaʻa i nā kiko kikoʻī a i ʻole nā pūnaewele, a e hōʻemi i nā hopena ʻaoʻao o kekahi mau lāʻau. Ke hoʻomau nei ka noiʻi a me ka hoʻomohala ʻana e hoʻomaikaʻi i ka kūpaʻa, ka hoʻouka ʻana i ka lāʻau lapaʻau, a me ka huli ʻana i nā hiki o nā huahana liposomal-based phospholipid no kahi ākea o nā noi therapeutic.
Hāʻawi kēia ʻike kikoʻī i nā ʻike i ka ulu ʻana o ka noiʻi phospholipid, me nā ʻano o kēia manawa, nā noi ʻoihana a me nā lāʻau lapaʻau, nā kuhikuhi a me nā pilikia e hiki mai ana, a me ka hoʻomohala ʻana i nā huahana liposomal-based phospholipid. Hōʻike kēia ʻike i nā hopena like ʻole a me nā manawa kūpono e pili ana i nā phospholipids ma nā ʻano āpau.
VI. Ka hopena
A. Ka hōʻuluʻulu o nā ʻike nui
ʻO Phospholipids, ʻo ia nā ʻāpana koʻikoʻi o nā membrane biological, pāʻani koʻikoʻi i ka mālama ʻana i ke ʻano a me ka hana. Ua hōʻike ʻia ka noiʻi i nā kuleana like ʻole o ka phospholipids i ka hōʻailona kelepona, ka membrane dynamics, a me ka metabolism lipid. Ua ʻike ʻia nā papa kikoʻī o nā phospholipids i nā hana ʻokoʻa i loko o nā cell, e hoʻohuli ana i nā kaʻina hana e like me ka ʻokoʻa cell, proliferation, a me apoptosis. Eia kekahi, ua puka mai ka pilina paʻakikī ma waena o nā phospholipids, nā lipids ʻē aʻe, a me nā protein membrane ma ke ʻano he kumu nui o ka hana cellular. Hoʻohui ʻia, loaʻa i nā phospholipids nā noi ʻoihana koʻikoʻi, ʻoi loa i ka hana ʻana i nā emulsifiers, stabilizers, a me nā ʻōnaehana lawe lāʻau. ʻO ka hoʻomaopopo ʻana i ke ʻano a me ka hana o nā phospholipids e hāʻawi i nā ʻike i kā lākou hiki ke hoʻohana i ka therapeutic a me ka ʻoihana.
B. Nā hopena no ke olakino a me ka ʻoihana
ʻO ka ʻike piha ʻana o ka phospholipids he hopena koʻikoʻi no ke olakino a me ka ʻoihana. I ka pōʻaiapili o ke olakino, pono nā phospholipids no ka mālama ʻana i ka pono a me ka hana o ka cellular. Hoʻopili ʻia nā imbalances i ka haku mele phospholipid me nā maʻi like ʻole, me nā maʻi metabolic, nā maʻi neurodegenerative, a me ke kanesa. No laila, hiki ke loaʻa i nā hana i manaʻo ʻia e hoʻololi i ka metabolism phospholipid a me ka hana. Eia kekahi, ʻo ka hoʻohana ʻana i nā phospholipids i nā ʻōnaehana lawe lāʻau e hāʻawi i nā ala hoʻohiki no ka hoʻomaikaʻi ʻana i ka pono a me ka palekana o nā huahana lāʻau. I ka ʻoihana ʻenehana, hoʻohui ʻia nā phospholipids i ka hana ʻana o nā mea kūʻai aku like ʻole, me nā emulsion meaʻai, nā mea hoʻonaninani, a me nā ʻano lāʻau lapaʻau. ʻO ka hoʻomaopopo ʻana i ka pilina hana-hana o nā phospholipids hiki ke hoʻoikaika i ka hana hou i kēia mau ʻoihana, e alakaʻi ana i ka hoʻomohala ʻana i nā huahana hou me ka hoʻomaikaʻi ʻana i ka paʻa a me ka bioavailability.
C. Nā manawa kūpono no ka noiʻi hou ʻana a me ka hoʻomohala ʻana
Hoʻomau ka noiʻi ʻana i ka ʻepekema phospholipid i nā ala he nui no ka ʻimi hou a me ka hoʻomohala ʻana. ʻO kahi ʻāpana koʻikoʻi ʻo ka wehewehe ʻana i nā mīkini molekala i lalo o ke komo ʻana o nā phospholipids i nā ala hōʻailona kelepona a me nā kaʻina hana maʻi. Hiki ke hoʻohana ʻia kēia ʻike e hoʻomohala i nā lāʻau lapaʻau e hoʻololi i ka metabolism phospholipid no ka pono therapeutic. Eia kekahi, ʻo ka noiʻi hou ʻana i ka hoʻohana ʻana i nā phospholipids e like me nā kaʻa lawe lāʻau lapaʻau a me ka hoʻomohala ʻana i nā ʻano lipid-based formulations e holomua i ke kahua o nā lāʻau lapaʻau. I ka ʻoihana ʻenehana, hiki i ka hoʻomau ʻana o ka noiʻi a me ka hoʻomohala ʻana i ka hoʻoikaika ʻana i nā kaʻina hana a me nā noi o nā huahana phospholipid e hoʻokō i nā koi o nā mākeke mea kūʻai aku. Eia kekahi, ʻo ka ʻimi ʻana i nā kumu hoʻomau hoʻomau a me ke kaiapuni o ka phospholipids no ka hoʻohana ʻana i ka ʻoihana kahi wahi koʻikoʻi no ka hoʻomohala ʻana.
No laila, ʻo ka ʻike ākea o ka ʻepekema phospholipid e hōʻike ana i ke koʻikoʻi koʻikoʻi o ka phospholipids i ka hana cellular, ko lākou hiki ke hoʻomaʻamaʻa i ka mālama olakino, a me kā lākou mau noi ʻoihana like ʻole. ʻO ka hoʻomau ʻana i ka noiʻi phospholipid e hāʻawi i nā manawa hoihoi no ka hoʻoponopono ʻana i nā pilikia e pili ana i ke olakino a me ka hoʻokele ʻana i nā mea hou i nā ʻoihana like ʻole.
Kuhikuhi:
Vance, DE, & Ridgway, ND (1988). ʻO ka methylation o ka phosphatidylethanolamine. Holomua i ka Lipid Research, 27 (1), 61-79.
Cui, Z., Houweling, M., & Vance, DE (1996). ʻO ka'ōlelo o ka phosphatidylethanolamine N-methyltransferase-2 ma McArdle-RH7777 hepatoma pūnaewele e hoʻoponopono hou i ka phosphatidylethanolamine intracellular a me nā loko triacylglycerol. Nūpepa o ka Biological Chemistry, 271(36), 21624-21631.
Hannun, YA, & Obeid, LM (2012). Nui nā ceramides. Ka Nūpepa o Biological Chemistry, 287(23), 19060-19068.
Kornhuber, J., Medlin, A., Bleich, S., Jendrossek, V., Henlin, G., Wiltfang, J., & Gulbins, E. (2005). ʻO ka hana kiʻekiʻe o ka acid sphingomyelinase i ke kaumaha nui. Nūpepa o ka Neural Transmission, 112(12), 1583-1590.
Krstic, D., & Knuesel, I. (2013). Ka wehewehe ʻana i ke ʻano o ka maʻi Alzheimer hope loa. Nature Reviews Neurology, 9 (1), 25-34.
Jiang, XC, Li, Z., & Liu, R. (2018). Andreotti, G, Ke nānā hou nei i ka loulou ma waena o Phospholipids, Inflammation a me Atherosclerosis. Lipidology Clinical, 13, 15-17.
Halliwell, B. (2007). Biochemistry o ke kaumaha oxidative. Nā Kūʻai Lahui Biochemical, 35 (5), 1147-1150.
Lattka, E., Illig, T., Heinrich, J., & Koletzko, B. (2010). Mālama anei nā ʻakika momona i ka waiū kanaka mai ka momona? International Journal of Obesity, 34 (2), 157-163.
Cohn, JS, & Kamili, A. (2010). ʻO Wat, E, & Adeli, K, Nā hana e kū nei o ka proprotein convertase subtilisin / kexin type 9 inhibition i ka lipid metabolism a me ke atherosclerosis. Nā Hōʻike Atherosclerosis o kēia manawa, 12 (4), 308-315.
Zeisel SH. Choline: koʻikoʻi koʻikoʻi i ka wā o ka ulu ʻana o ka fetal a me nā pono meaʻai i nā pākeke. Annu Rev Nutr. 2006;26:229-50. doi: 10.1146/annurev.nutr.26.061505.111156.
Liu L, Geng J, Srinivasarao M, et al. ʻO Phospholipid eicosapentaenoic acid-enriched phospholipids e hoʻomaikaʻi i ka hana neurobehavioral i nā ʻiole ma hope o ka hōʻeha lolo hypoxic-ischemic neonatal. Pediatr Res. 2020;88(1):73-82. doi: 10.1038/s41390-019-0637-8.
ʻO Garg R, Singh R, Manchanda SC, Singla D. Ke kuleana o nā ʻōnaehana lawe lāʻau hou me ka hoʻohana ʻana i nā nanostars a i ʻole nanospheres. Afr Hema J Bot. 2021;139(1):109-120. doi: 10.1016/j.sajb.2021.01.023.
Kelley, EG, Albert, AD, & Sullivan, MO (2018). Membrane lipids, Eicosanoids, and the Synergy of Phospholipid Diversity, Prostaglandins, and Nitric Oxide. Handbook of Experimental Pharmacology, 233, 235-270.
van Meer, G., Voelker, DR, & Feigenson, GW (2008). ʻO nā lipid membrane: ma hea lākou a pehea lākou e hana ai. Nature Reviews Molecular Cell Biology, 9(2), 112-124.
Benariba, N., Shambat, G., Marsac, P., & Cansell, M. (2019). ʻO nā holomua ma ka ʻenehana Synthesis o Phospholipids. ChemPhysChem, 20(14), 1776-1782.
Torchilin, VP (2005). ʻO nā holomua hou me nā liposomes ma ke ʻano he mea lawe lāʻau. Nature Reviews Drug Discovery, 4(2), 145-160.
Brezesinski, G., Zhao, Y., & Gutberlet, T. (2021). ʻO nā hui Phospholipid: topology o ke poʻo, uku, a me ka hiki ke hoʻololi. Manaʻo o kēia manawa ma Colloid & Interface Science, 51, 81-93.
Abra, RM, & Hunt, CA (2019). Liposomal Drug Delivery Systems: He loiloi me nā haʻawina mai Biophysics. Nā Manaʻo Kemika, 119(10), 6287-6306.
Allen, TM, & Cullis, PR (2013). Nā ʻōnaehana hāʻawi lāʻau liposomal: mai ka manaʻo a hiki i nā noi lapaʻau. Nā Manaʻo Hoʻolaha Lapaʻau Kiʻekiʻe, 65 (1), 36-48.
Vance JE, Vance DE. ʻO ka biosynthesis phospholipid i loko o nā pūnaewele mammalian. Biochem Cell Biol. 2004;82(1):113-128. doi:10.1139/o03-073
van Meer G, Voelker DR, Feigenson GW. ʻO nā lipid membrane: ma hea lākou a pehea lākou e hana ai. Nat Rev Mol Cell Biol. 2008;9(2):112-124. doi:10.1038/nrm2330
ʻO Boon J. ʻO ke kuleana o nā phospholipids i ka hana o nā protein membrane. Biochim Biophys Acta. 2016;1858(10):2256-2268. doi:10.1016/j.bbamem.2016.02.030
Ka manawa hoʻouna: Dec-21-2023
