I. Hoolauna
Hoʻolauna
ʻO ka lau ginkgohe mea hana maoli i unuhi ʻia mai nā lau ginkgo. ʻO kāna mau mea nui he flavonoids a me ginkgo lactones. He PAF kūikawā ia (platelet-activating factor, platelet-activating factor) receptor antagonist. ʻO kāna mau hana pharmacological: hoʻomaikaʻi i ka cerebral circulation a me ka metabolism cell; e hoʻonui ana i ka hana o ke koko ʻulaʻula superoxide dismutase (SOD) a me ka glutathione peroxidase (GSH-px), a me ka hoʻemi ʻana i ka membrane cell peroxidized lipids (MDA). ka hana ʻana, hoʻomaʻemaʻe i nā radical manuahi, pale i ka hōʻino ʻana i nā cardiomyocytes a me nā cell endothelial vascular; e hoʻopaʻapaʻa i ka platelet aggregation, micro thrombosis, a me nā maʻi lipid metabolism i hoʻokumu ʻia e ka platelet PAF; hoʻomaikaʻi i ke kahe coronary o ka puʻuwai a pale i ka myocardium ischemic; Hoʻonui i ka deformability o ke koko ʻulaʻula, hoʻemi i ka viscosity koko, a hoʻopau i nā maʻi microcirculatory; pale i ka synthesis o ka thromboxane (TXA2) a hoʻoulu i ka hoʻokuʻu ʻana o ka prostaglandin PGI2 mai nā ʻāpana endothelial vascular.
Puna Mea kanu
ʻO Ginkgo biloba ka lau o Ginkgo biloba L., kahi mea kanu o ka ʻohana Ginkgo. Loaʻa i kāna extract (EGB) nā ʻano hana mālama olakino a hoʻohana nui ʻia i ka meaʻai a me nā mea hoʻonaninani. He paʻakikī loa ka hui ʻana o nā lau Ginkgo, me ka ʻoi aku o 140 mau pūhui i hoʻokaʻawale ʻia mai ia mea. ʻO Flavonoids a me terpene lactone nā mea hana nui ʻelua o nā lau Ginkgo. Eia kekahi, loaʻa pū kekahi i ka polyprenol, nā waikawa organik, polysaccharides, amino acids, phenols, a me nā mea trace. Wahi a nā helu helu piha ʻole, ʻo ka ʻāpana lau ginkgo maʻamau o kēia manawa ʻo EGb761 i hana ʻia e like me ke kaʻina hana patent a Germany's Schwabe. ʻIke ʻia me he pauda ʻeleʻele-melemele a he ʻala iki o ka lau ginkgo. ʻO ka hui kemika he 24% flavonoids, 6% terpene lactones, emi iho ma mua o 0.0005% ginkgo acid, 7.0% proanthocyanidins, 13.0% carboxylic acids, 2.0% catechins, 20% non-flavonoid glycosides, a me 4.0 polymer compounds. %, mea anoano 5.0%, mea hoʻoheheʻe wai 3.0%, nā mea ʻē aʻe 3.0%.
Nā ʻano Antioxidant a me ka Mechanism
Hiki iā Ginkgo lau extract ke hoʻopau pololei i nā radical free lipid, lipid peroxidation free radicals alkane free radicals, etc., a hoʻopau i ke kaulahao hoʻololi manuahi. I ka manawa like, hiki iā ia ke hoʻoponopono a hoʻomaikaʻi i ka hana o nā enzyme antioxidant e like me ka superoxide dismutase a me ka glutathione peroxidase. ʻOi aku ka hopena antioxidant o nā flavonoids ma EGB ma mua o nā huaora, a loaʻa iā ia nā waiwai anti-free radical attack in vitro.
ʻOkoʻa nā hopena antioxidant o nā extracts ginkgo i unuhi ʻia e nā ʻano ʻano like ʻole, a ʻokoʻa hoʻi nā hopena antioxidant o nā mea ʻala a me nā huahana i hoʻomaʻemaʻe ʻia. Ma Xihan et al. Ua ʻike ʻia ʻo ka petroleum ether-ethanol extract ka ikaika loa o ka hopena antioxidant ma ka ʻaila rapeseed i hoʻohālikelike ʻia me nā ʻāpana lau Ginkgo i loaʻa i nā ʻano hoʻomākaukau like ʻole. ʻOi aku ka kiʻekiʻe o ka mana antioxidant o ka ʻōpala lau Ginkgo ma mua o ka extract i hoʻomaʻemaʻe ʻia. Ma muli paha o ka crude Loaʻa i ka extract nā mea antioxidant ʻē aʻe, e like me nā waikawa organik, amino acids, tannins, alkaloids, a me nā mea ʻē aʻe i loaʻa nā hopena synergistic.
Hana Hoʻomākaukau
(1) Organic solvent extraction method I kēia manawa, ʻo ke ʻano i hoʻohana nui ʻia ma ka home a me nā ʻāina ʻē ʻo ke ʻano hoʻoheheʻe organik. No ka mea he mea ʻawaʻawa a i ʻole nā mea hoʻoheheʻe organik ʻē aʻe, hoʻohana mau ʻia ka ethanol ma ke ʻano he mea lawe. ʻO nā hoʻokolohua a Zhang Yonghong a me nā mea ʻē aʻe i hōʻike ʻia ʻo nā kūlana maikaʻi loa no ka unuhi ʻana i nā flavonoids mai nā lau ginkgo he 70% ethanol ma ke ʻano he hopena hoʻoheheʻe, ʻo ka mahana o ka hoʻoiho ʻana he 90 ° C, ʻo ka ratio paʻa-wai he 1:20, ʻo ka helu o nā extraction he 3 manawa, a i kēlā me kēia manawa refluxes no 1.5 hola.
(2) Ua hōʻike ʻia nā hoʻokolohua ʻo Wang Hui et al. ua hoʻonui nui ʻia ka nui o nā flavonoids ma hope o ka hoʻomaʻamaʻa ʻana o ka lau ginkgo me ka cellulase a unuhi ʻia, a hiki i ka 2.01%.
(3) Ultrasonic extraction method Ma hope o ka hoʻomaʻamaʻa ultrasonic o nā lau ginkgo, ua haki ka membrane cell, a ua wikiwiki ka neʻe ʻana o nā ʻāpana lau, e hāpai ana i ka hoʻopau ʻana o nā mea hana. No laila, kani ultrasonic unuhi o flavonoids i nui pono. ʻO nā hopena hoʻokolohua i loaʻa e Liu Jingzhi et al. hōʻike i nā kūlana kaʻina o ka ultrasonic extraction: kani ultrasonic alapine 40kHz, kani ultrasonic lapaʻau manawa 55min, wela 35 °C, a kū no 3h. I kēia manawa, ʻo 81.9% ka nui o ka unuhi.
Palapala noi
ʻO nā flavonoids i loko o nā lau Ginkgo he mau waiwai antioxidant a hiki ke hoʻohui ʻia i nā aila a me nā pastries e like me nā antioxidants. ʻO ka nui o nā flavonoids he melemele a he ākea ka hoʻoheheʻe ʻia, hiki ke hoʻohana ʻia ka nui o nā flavonoids no ke kala. hopena ʻākena. Hana ʻia ʻo Ginkgo biloba i ka pauka ultrafine a hoʻohui ʻia i ka meaʻai. Hoʻopili ʻia nā lau Ginkgo a hoʻohui ʻia i nā keke, nā kuki, nā noodles, nā candies, a me ka ice cream ma ka nui o 5% a 10% e hoʻoponopono iā lākou i nā meaʻai lau ginkgo me nā hopena mālama ola.
Hoʻohana ʻia ʻo Ginkgo leaf extract ma ke ʻano he meaʻai meaʻai ma Kanada a ua ʻae ʻia ma ke ʻano he lāʻau lapaʻau ma luna o Germany a me Farani. Aia ka lau Ginkgo i loko o ka United States Pharmacopoeia (24th edition) a hiki ke hoʻohana ʻia ma ke ʻano he meaʻai meaʻai ma ʻAmelika Hui Pū ʻIa.
Nā hopena lāʻau lapaʻau
1. Ka hopena ma ka ʻōnaehana cardiovascular
(1) Hiki i ka lau ginkgo ke pale i ka hana o ka angiotensin-converting enzyme (ACE) i loko o ka serum kanaka maʻamau, ma laila e pale ai i ka hoʻopaʻa ʻana o nā arterioles, ka hoʻonui ʻana i nā kīʻaha koko, a me ka hoʻonui ʻana i ke kahe koko.
(2) Hiki i ka lau o Ginkgo ke pale i ka emi ʻana o ka myocardial i nā ʻiole kāne i hoʻoiho ʻia e ka bupivacaine intravenous, ke kāohi i ka hoʻopaʻa ʻana o ke aʻa coronary i loko o ke kanaka a me nā puaʻa i hoʻokumu ʻia e ka hypoxia, a hoʻopau i ka PAF (platelet-activating factor) ke kumu o ka arrhythmia i nā ʻīlio. Hiki iā ia ke pale i ka hana ʻino o ka naʻau i hoʻokumu ʻia e nā allergies cardiac i nā puaʻa guinea kaʻawale.
(3) Hiki ke hoʻonui nui ʻia nā kīʻaha koko cerebral o nā pōpoki a me nā ʻīlio i hoʻomaʻamaʻa ʻia, hoʻonui i ke kahe koko cerebral, a hoʻemi i ka pale ʻana i ka cerebral vascular resistance. Hiki i ka lau ginkgo ke pale i ka piʻi ʻana o ka mesenteric microvascular diameter i hoʻokumu ʻia e ka endotoxin intravenous. I loko o ka canine endotoxin model, Ginkgo biloba extract inhibits hemodynamic loli; i ke kumu hoʻohālike hipa, ʻo Ginkgo biloba extract ke kāohi i ka hypertension a me ka edema pulmonary i hoʻokumu ʻia e ka maʻi kahe lymphatic i hana ʻia e ka endotoxin.
(4) Hoʻokomo ʻia nā ʻiole me ka 5ml/kg o nā flavonoids lau ginkgo i kēlā me kēia lā. Ma hope o 40 mau lā, ua hoʻemi nui ʻia ka maʻi triglyceride serum. Ua hāʻawi waha ʻia ʻo Ginkgo biloba extract (20 mg/kg i kēlā me kēia lā) i nā lapeti e loaʻa ana i kahi meaʻai maʻamau a hypercholesterolemic. Ma hope o hoʻokahi mahina, ua hoʻemi nui ʻia ke kiʻekiʻe o ka cholesterol hyper-esterified i loko o ka plasma a me ka aorta o nā rabbit e loaʻa ana i kahi meaʻai atherogenic. Akā naʻe, ʻaʻole i loli nā pae cholesterol manuahi.
(5) ʻO Ginkgo terpene lactone kahi mea paʻa paʻa paʻa PAF. Hiki i ka ʻāpana lau ginkgo a i ʻole ginkgo terpene lactone ke kāohi i ka platelet-activating factor (PAF) a me ka cyclooxygenase a i ʻole lipoxygenase. Ua ʻae maikaʻi ʻia ka ʻāpana lau Ginkgo a me ka hoʻohui ʻana i nā platelet antagonized i hoʻokumu ʻia e PAF akā ʻaʻole i pili i ka hoʻohui ʻia e ADP.
2. Ka hopena ma ke kikowaena o ke kino
(1) Hoʻopili ka lau ʻo Ginkgo i ka ʻōnaehana endocrine a me ka launa pū ʻana ma waena o ka ʻōnaehana pale a me ka ʻōnaehana nūnū waena ma ke kāohi ʻana i ka hana a PAF. Hiki iā ia ke hoʻoikaika i ka metabolism o ka lolo a hoʻomaikaʻi i ka hana hoʻomanaʻo.
(2) He mau hopena antidepressant ko Ginkgo terpene lactones, a pili ko lākou mau hopena antidepressant i ka pūnaeho puʻupuʻu monoaminergic waena.
(3) Ma waho aʻe o ka hiki ke hoʻomaikaʻi maikaʻi ʻia ka lau o Ginkgo i ka hemahema o ka hoʻomanaʻo ʻana e NaNO2, hiki ke pili i kona hopena anti-hypoxic i kona hoʻonui ʻana i ke kahe koko cerebral a me ka hoʻomaikaʻi ʻana o ka ikehu o ka lolo i ka wā hypoxia.
(4) Hoʻomaikaʻi maikaʻi loa ka ʻāpana lau Ginkgo i nā maʻi ʻeha o ka lolo i hana ʻia e ka ligation a me ka recirculation o nā aʻa carotid ʻelua a pale i ka pōʻino o ka lolo i nā gerbils i hoʻokumu ʻia e ka ischemia a me ka congestion; hoʻonui i ka hana o nā ʻīlio ma hope o ka multi-focal brain ischemia ʻO ka hoʻihoʻi mua ʻana o ka neuronal a me ka hōʻemi ʻana i ka pōʻino neuronal ma hope o ka ischemia ma ka hippocampus o ka lolo gerbil; hoʻemi nui i ka nalowale o ATP, AMP, creatine a me creatine phosphate i loko o ka lolo ischemic o ka ʻīlio mongrel. He mea pono ka Ginkgo biloba lactone B i ka lapaau ana i ka hahau.
3. Ka hopena ma ka ʻōnaehana digestive
(1) Hiki ke hoʻomaikaʻi maikaʻi i ka ʻōpū o ka ʻōpū a me ka ʻōpū o ka ʻiole i ka ʻiole e ka PAF a me ka endotoxin, a hiki ke pale i ka pōʻino o ka ʻōpū ma muli o ka ethanol.
(2) I nā ʻiole me ka ate cirrhosis i hoʻokumu ʻia e ka bile duct ligation, ʻo ka hoʻoheheʻe ʻia ʻana o ka lau ginkgo i hoʻohaʻahaʻa nui ʻia i ke kahe o ka hepatic portal venous pressure, cardiac index, kahe koko o nā lālā vein portal, a me ka hoʻomaikaʻi ʻana i ka hoʻomanawanui vascular systemic i hoʻohālikelike ʻia me placebo. Hōʻike kēia i ka loaʻa ʻana o ka lau ginkgo i ka hopena therapeutic i ka cirrhosis ate. Hiki iā ia ke ālai i ka hoʻokumu ʻana o nā radical free oxygen i ka ʻiole acute pancreatitis ma muli o ka cholecystokinin. He kuleana ko Ginkgo terpene lactone B i ka mālama ʻana i ka maʻi pancreatitis.
4. Ka hopena ma ka ʻōnaehana hanu
(1) He hopena hoʻomaha pololei ka ethanol extract o Ginkgo biloba i ka ʻiʻo maʻemaʻe tracheal a hiki ke hōʻoluʻolu i nā hopena spasmodic o ka histamine phosphate a me ka acetylcholine ma ka trachea kaʻawale o nā puaʻa guinea, a pale i ka hoʻouka ʻana o ka hānō histamine i nā puaʻa guinea.
(2) Intravenous injection of Ginkgo leaf extract hiki ke kāohi i ka bronchoconstriction a me ka hyperresponsiveness o nā ʻiole i hoʻoulu ʻia e PAF a me ka ovalbumin, a pale i ka bronchoconstriction i hana ʻia e nā antigens, akā ʻaʻole pili i ka hyperresponsiveness bronchial i hoʻokumu ʻia e indomethacin.
(3) ʻO ka inhalation o ka aerosolized Ginkgo leaf extract ʻaʻole wale i kaohi ʻana i ka bronchoconstriction akā ke kāohi pū nei hoʻi i ka hōʻemi ʻana o nā keʻokeʻo keʻokeʻo a me nā eosinophils i hoʻokumu ʻia e PAF. He mea koʻikoʻi loa ka ʻāpana lau Ginkgo i ka pale ʻana a me ka mālama ʻana i ka hyperresponsiveness bronchial.
5. Ka hopena anti-kahiko
ʻO nā ginkgobiflavonoids, isoginkgobiflavonoids, ginkgo biloba, a me ka quercetin i loko o nā lau ginkgo e pale i ka lipid peroxidation, ʻoiai ʻoi aku ka ikaika o ka quercetin. Ua hana ʻia nā hoʻokolohua ma luna o nā ʻiole a ua ʻike ʻia ʻo ka nui o nā flavonoids lau ginkgo i unuhi ʻia i ka wai (0.95mg/ml) hiki ke hōʻemi nui i ka lipid peroxidation, a me nā flavonoids lau ginkgo i unuhi ʻia i ka wai (1.9mg/ml) hiki ke hoʻonui i ka serum copper a me ka zinc SOD. hana a hoemi Ka hopena o ke koko viscosity oiai e hoemi ana i ka hana SGPT.
7. Ke kuleana i ka hōʻole ʻana i ka transplant a me nā ʻano ʻē aʻe
Hiki ke hoʻolōʻihi i ka manawa ola o nā grafts ʻili, heterotopic heart xenografts, a me orthotopic ate xenografts. Hiki i ka lau ginkgo ke keakea i ka hana o ke kino pepehi kanaka maoli e ku e i KC526 mau keena kuia, a hiki no hoi ke pale i ka hana pepehi kanaka maoli i hanaia e ka interferon.
8. Ka hopena anti-tumor
ʻO ka ʻāpana ʻōpala o nā lau ʻōmaʻomaʻo o Ginkgo biloba, ka ʻāpana momona, hiki ke pale i ka maʻi Epstein-Barr. ʻO ka Heptadecene salicylic acid a me ka bilo-betin he hana pale ikaika; hiki i ka nui o nā flavonoids o Ginkgo ke hoʻonui i ke kaumaha o nā ʻiole e lawe ana i ka maʻi tumora. a me nā pae hana SOD, e hoʻoneʻe ana i ka mana kūʻokoʻa anti-tumor o ke kino; Hiki i ka quercetin a me ka myricetin ke pale i ka hiki ʻana mai o nā carcinogens.
Nā memo a me nā Contraindications
ʻO nā hopena maikaʻi ʻole o ka lāʻau Ginkgo: i kekahi manawa ka pilikia ʻole o ka ʻōpū, e like me ka anorexia, nausea, constipation, nā ʻōpū, ka ʻōpū o ka ʻōpū, etc.; hiki ke hoʻonui ʻia ka puʻuwai puʻuwai, luhi, a me nā mea ʻē aʻe, akā ʻaʻole pili kēia i ka mālama ʻana. Ma hope o ka hoʻoponopono waha lōʻihi, pono e nānā mau i nā hōʻailona kūpono o ka rheology koko. Inā loaʻa iā ʻoe nā hōʻailona gastrointestinal, hiki iā ʻoe ke lawe ma hope o ka ʻai.
Pilikia laau
He hopena synergistic kēia huahana ke hoʻohana pū ʻia me nā lāʻau hoʻohaʻahaʻa viscosity koko ʻē aʻe, e like me ka sodium alginate diester, acetate, etc., hiki ke hoʻomaikaʻi i ka pono.
Kaulana Hoʻomohala
Loaʻa i nā lau Ginkgo kahi liʻiliʻi o nā proanthocyanidins a me nā ʻakika urushiolic, kahi mea ʻona i ke kino o ke kanaka. Ke waiho ʻia ka ginkgo ma ke ʻano he mea maka no ka hoʻomaʻamaʻa ʻana i ka meaʻai, pono ka mālama kūikawā e hōʻemi i ka ʻike o ka proanthocyanidins a me nā waikawa urushiolic. Eia nō naʻe, i loko o ka pae hoʻohana ʻia i kēia manawa, ʻaʻohe mea ʻawaʻawa a i ʻole ka maʻi maʻi a ʻaʻohe hopena teratogenic. Ua ʻae ka Ministry of Health i ka ʻai ʻana o Ginkgo biloba ma ke ʻano he meaʻai hou i ka makahiki 1992. I nā makahiki i hala iho nei, ua hoʻohana nui ʻia ka Ginkgo biloba total flavonoids i ka ʻoihana meaʻai, a ʻo ka noiʻi a me ka hoʻomohala ʻana o Ginkgo biloba he ākea ākea.
Kāhea iā mā˚ou
Grace HU (Luna Kūʻai)grace@biowaycn.com
ʻO Carl Cheng ( Luna Nui / Luna )ceo@biowaycn.com
Pūnaewele:www.biowaynutrition.com
Ka manawa hoʻouna: Sep-12-2024