Lycorine Hydrochloride
ʻO Lycorine hydrochloride ka pauka keʻokeʻo keʻokeʻo o ka lycorine alkaloid, i loaʻa i nā mea kanu o Lycoris radiata (L'Her.), a no ka ʻohana Amaryllidaceae. Loaʻa i ka Lycorine hydrochloride nā hopena pharmacological like ʻole, me ka anti-tumor, anti-cancer, anti-HCV, anti-inflammatory, anti-bacterial, anti-virus, anti-angiogenesis, a me nā waiwai anti-malaria. Hiki ke hoʻoheheʻe ʻia i ka wai, DMSO, a me ka ethanol. Hōʻike ʻia kona ʻano kemika e kahi ʻano steroidal paʻakikī me ka ʻono ʻawaʻawa me nā pūʻulu hana he nui, me nā hui hydroxyl a me nā amino, e hāʻawi ana i kāna mau hana olaola.
| inoa huahana | Lycorine hydrochloride CAS:2188-68-3 | ||
| Puna Mea kanu | Lycoris | ||
| Kūlana mālama | E mālama me kahi sila ma ka lumi wela | La hoike | 2024.08.24 |
| 'ikamu | Kūlana | Ka hopena |
| Maemae（HPLC） | Lycorine hydrochloride≥98% | 99.7% |
| Ka nana aku | pauda keʻokeʻo keʻokeʻo | Kūlike |
| ʻAno kinoics | ||
| ʻĀpana-nui | NLT100% 80Mesh | Kūlike |
| Pohō ma ka maloʻo | ≤1.0% | 1.8% |
| Kaumaha metala | ||
| Huina metala | ≤10.0ppm | Kūlike |
| Ke alakaʻi | ≤2.0ppm | Kūlike |
| Mercury | ≤1.0ppm | Kūlike |
| Cadmium | ≤0.5ppm | Kūlike |
| Microorganism | ||
| Huina helu o ka bacteria | ≤1000cfu/g | Kūlike |
| hū | ≤100cfu/g | Kūlike |
| Escherichia coli | ʻAʻole i komo | ʻAʻole ʻike ʻia |
| Salmonella | ʻAʻole i komo | ʻAʻole ʻike ʻia |
| Staphylococcus | ʻAʻole i komo | ʻAʻole ʻike ʻia |
| Nā hopena | Kupono | |
Nā hiʻohiʻona:
(1) Maʻemaʻe Kiʻekiʻe:Hoʻomaʻamaʻa maikaʻi ʻia kā mākou huahana e hōʻoia i kahi kiʻekiʻe o ka maʻemaʻe, he mea koʻikoʻi ia no ka pono a me ka palekana i nā noi like ʻole.
(2) Nā Pono Anticancer:Ua hōʻike ʻo ia i nā hopena anticancer koʻikoʻi e kūʻē i nā ʻano maʻi maʻi like ʻole, i loko o vitro a i loko o vivo, ma o nā hana e like me ka hoʻoulu ʻana i ka hopu ʻana o ka cell cycle, triggering apoptosis, a me ka pale ʻana i ka angiogenesis.
(3) Nā hana i hoʻopaʻa ʻia:Manaʻo ʻia ʻo Lycorine hydrochloride e launa pū me nā pahuhopu molekala he nui, e hāʻawi ana i ka mana ākea ākea e kūʻē i nā maʻi maʻi maʻi.
(4) Haʻahaʻa ʻawaʻawa:Hōʻike ʻo ia i ka haʻahaʻa haʻahaʻa i nā cell maʻamau, kahi mea nui i kona hoʻohana ʻana ma ke ʻano he lāʻau lapaʻau.
(5) Hōʻike Pharmacokinetic:Ua aʻo ʻia ka huahana no kāna pharmacokinetics, e hōʻike ana i ka absorption wikiwiki a me ka hoʻopau wikiwiki ʻana mai ka plasma, he mea nui ia no ka hoʻolālā ʻana a me ka hoʻolālā ʻana.
(6) Nā Hana Hana Hana:Ua hōʻike ʻo Lycorine hydrochloride i nā hopena i hoʻonui ʻia ke hoʻohana pū ʻia me nā lāʻau lapaʻau ʻē aʻe, hiki ke hoʻopōmaikaʻi i ka pale ʻana i ka lāʻau a me ka hoʻomaikaʻi ʻana i nā hopena lapaʻau.
(7) Kākoʻo ʻia i ka noiʻi:Kākoʻo ʻia ka huahana e ka noiʻi nui, hāʻawi i kahi kumu paʻa no kona hoʻohana ʻana i ka hoʻomohala lāʻau lapaʻau a me nā noi lapaʻau.
(8) Hōʻoia maikaʻi:Aia nā hana hoʻomalu maikaʻi koʻikoʻi i loko o ke kaʻina hana e hōʻoia i ka kūlike a me ka hilinaʻi o ka huahana.
(9) Nā mea hoʻohana like ʻole:He kūpono no ka hoʻohana ʻana i ka noiʻi a me ka hoʻomohala ʻana no nā noi lāʻau lapaʻau, me ka loaʻa ʻana o ka lāʻau lapaʻau a me ka hoʻomohala ʻana i ka maʻi kanesa.
(10) Hoʻokō:Hana ʻia ma muli o nā kūlana GMP e hōʻoia i ka palekana a me ka pono o ka huahana.
(1) ʻoihana lāʻau lapaʻau:Hoʻohana ʻia ʻo Lycorine hydrochloride i ka hoʻomohala ʻana i nā lāʻau antiviral a me anticancer.
(2) ʻOihana Biotechnology:Hoʻohana ʻia ia i ka noiʻi ʻana a me ka hoʻomohala ʻana i nā mea lapaʻau hou a me nā ʻano lāʻau lapaʻau.
(3) Ka noiʻi huahana kūlohelohe:Ua aʻo ʻia ʻo Lycorine hydrochloride no kāna mau pono olakino a me nā waiwai lāʻau.
(4) ʻOihana Kimia:Hiki ke hoʻohana ʻia ma ke ʻano he waena kemika i ka synthesis o nā pūhui ʻē aʻe.
(5) ʻOihana mahiʻai:Ua noiʻi ʻia ʻo Lycorine hydrochloride no kona hiki ke lilo i pesticide kūlohelohe a me ka mea hoʻoponopono ulu.
ʻO ke kaʻina hana o ka lycorine hydrochloride ka mea maʻamau i kēia mau ʻanuʻu nui e hōʻoia i ka maʻemaʻe o ka solvent a hoʻomaikaʻi i ka helu hoʻihoʻi:
(1) Koho a me ka hoʻoponopono mua ʻana:E koho i nā mea kanu lāʻau Amaryllidaceae kūpono, e like me nā ʻōpuʻu Amaryllis, a holoi, maloʻo a wāwahi iā lākou e hōʻoia i ka maʻemaʻe o nā mea maka a kau i ke kumu no ka unuhi ʻana ma hope.
(2)Ka hoʻomaʻamaʻa mua ʻana o ka enzyme:E hoʻohana i nā enzyme paʻakikī (e like me ka cellulase a me ka pectinase) e hoʻomaʻamaʻa mua i nā mea maka i ʻoki ʻia e hoʻoheheʻe i nā paia o nā mea kanu a hoʻomaikaʻi i ka pono o ka unuhi ʻana.
(3)E hoʻoheheʻe i ka waika hydrochloric:Hoʻohui i nā mea maka i hoʻomaʻamaʻa mua ʻia me ka dilute hydrochloric acid solution e unuhi i ka lycorine. ʻO ka hoʻohana ʻana i ka waika hydrochloric e kōkua i ka hoʻonui ʻana i ka solubility o ka lycorine, a laila e hoʻomaikaʻi ai i ka pono o ka unuhi.
(4)ʻO ka unuhi ʻana i kōkua ʻia me ka ultrasonic:Hiki i ka hoʻohana ʻana i ka ʻenehana hoʻoheheʻe ultrasonic ke kōkua i ka hoʻopau ʻana o ka lycorine i loko o ka solvent a hoʻomaikaʻi i ka maikaʻi a me ka maʻemaʻe.
(5)Ka unuhi ʻana o ka chloroform:Hana ʻia ka unuhi ʻana me nā mea hoʻoheheʻe organik e like me ka chloroform, a ua hoʻoneʻe ʻia ka lycorine mai ka aqueous phase a i ka organic phase no ka hoʻomaʻemaʻe hou ʻana i ka pūhui pahuhopu.
(6)Hoʻihoʻi hou i ka mea hoʻoheheʻe:Ma hope o ke kaʻina hana hoʻoheheʻe, hoʻihoʻi ʻia ka solvent ma o ka evaporation a i ʻole distillation e hōʻemi i ka hoʻohana ʻana i ka solvent a hoʻomaikaʻi i ka ʻoihana.
(7)Hoʻomaʻemaʻe a hoʻomaloʻo:Ma o ka hoʻomaʻemaʻe kūpono a me ka hoʻomaloʻo ʻana, loaʻa ka pauka lycorine hydrochloride maʻemaʻe.
Ma ke kaʻina hana holoʻokoʻa holoʻokoʻa, ʻo ka hoʻomalu ʻana i ke koho solvent, nā kūlana hoʻoheheʻe (e like me ka waiwai pH, ka mahana, a me ka manawa), a me nā hana hoʻomaʻemaʻe hope ke kī i ka hōʻoia ʻana i ka maʻemaʻe solvent a me ka hoʻomaikaʻi ʻana i ka helu hoʻihoʻi. ʻO ka hoʻohana ʻana i nā ʻenehana hou a me ka hoʻomaʻemaʻe ʻana, e like me nā ultrasonic extractors a me nā ʻōnaehana chromatography wai kiʻekiʻe (HPLC), kōkua pū kekahi i ka hoʻomaikaʻi ʻana i ka maikaʻi o ka unuhi a me ka maikaʻi o ka huahana.
Ka mālama ʻana: E mālama i kahi anuanu, maloʻo, a maʻemaʻe hoʻi, Pale i ka makū a me ke kukui pololei.
Puke nui: 25kg / pahu.
Lead Time: 7 lā ma hope o kāu kauoha.
Ke ola papa: 2 makahiki.
Manaʻo: Hiki ke hoʻokō ʻia nā kikoʻī kikoʻī.
Hōʻike
Ma lalo o 100kg, 3-5Days
ʻO ka lawelawe puka i ka puka maʻalahi ke kiʻi i nā waiwai
Ma ke Kai
Ma luna o 300kg, ma kahi o 30 mau lā
Pono ʻia ka ʻoihana hoʻomaʻamaʻa hoʻomaʻemaʻe ʻoihana no ke awa
Ma ka Lewa
100kg-1000kg, 5-7Days
Pono ke kahua mokulele i ka lawelawe ʻoihana ʻoihana hoʻomaʻemaʻe
Ua loaʻa iā Bioway Organic nā palapala hōʻoia USDA a me EU organik, BRC, ISO, HALAL, KOSHER, a me HACCP.
ʻO Lycorine kahi alkaloid kūlohelohe i hiki ke loaʻa i loko o nā mea kanu, ʻoi loa i loko o ka ʻohana Amaryllidaceae. Eia kekahi mau mea kanu i ʻike ʻia he lycorine.
Lycoris radiata(ʻike pū ʻia ʻo ka lilia spider ʻulaʻula a i ʻole manjushage) he lāʻau lapaʻau Kina i loaʻa i ka lycorine.
Leucojum aestivum(Summer snowflake), ua ʻike pū ʻia ka lycorine.
Ungernia sewertzowiihe mea kanu ʻē aʻe mai ka ʻohana Amaryllidaceae i hōʻike ʻia he lycorine.
Hippeastrum hybrid (ka Easter lilia)a me nā mea kanu ʻē aʻe e pili ana ʻo Amaryllidaceae nā kumu lycorine.
Hoʻolaha nui ʻia kēia mau mea kanu i nā ʻāpana ʻāina a me nā subtropical a puni ka honua a he moʻolelo lōʻihi ko ka hoʻohana ʻana i ka lāʻau lapaʻau kuʻuna. ʻO ka loaʻa ʻana o ka lycorine i loko o kēia mau mea kanu ke kumuhana o ka noiʻi ʻana ma muli o kāna mau waiwai pharmacological, me kāna mau hopena anticancer koʻikoʻi e like me ka hōʻike ʻana i nā haʻawina like ʻole.
ʻO Lycorine kahi alkaloid kūlohelohe me kahi ākea o nā hopena pharmacological, me kona hiki ke hoʻohana i ka mālama ʻana i ka maʻi kanesa. ʻOiai ua hōʻike ʻo ia i nā hopena hoʻohiki i nā haʻawina like ʻole, aia kekahi mau hopena ʻaoʻao a me nā noʻonoʻo e pili ana i ka hoʻohana ʻana:
Haʻahaʻa Haʻahaʻa: ʻO Lycorine a me kāna paʻakai hydrochloride ke hōʻike pinepine nei i ka ʻawaʻawa haʻahaʻa, he ʻano maikaʻi ia no nā noi lapaʻau. Ua hōʻike ʻia ka liʻiliʻi o nā hopena maikaʻi ʻole ma luna o nā pūnaewele kanaka maʻamau a me nā ʻiole olakino, e hōʻike ana i kahi pae o ka koho no nā maʻi maʻi maʻi ma luna o nā ʻiʻo maʻamau.
Nā hopena Emetic Transient: Ua ʻike ʻia ka nausea a me ka luaʻi ʻana ma hope o ka hoʻoheheʻe ʻia ʻana o ka lycorine hydrochloride i loko o ka subcutaneous a i ʻole intravenous, e hoʻemi mau ana i loko o 2.5 mau hola me ka ʻole e pili ana i ka palekana biochemical a hematological paha.
ʻAʻohe pilikia o ka hui ʻana o nā kaʻa: Ua hōʻike nā haʻawina ʻaʻole pili ka hopena o ka lycorine i ka hoʻohui ʻana i nā ʻiole, e like me ka hoʻāʻo ʻana e ka rotarod test, e hōʻike ana ʻaʻole ia e alakaʻi i nā hopena ʻaoʻao o ka central nervous system (CNS) pili i ka mana kaʻa.
Ka hopena i ka hana Locomotor Spontaneous: Ma kahi nui o 30 mg/kg, ua ʻike ʻia ka lycorine e hōʻemi i ka hana locomotor kuʻuna i nā ʻiole, e like me ka hōʻike ʻia e ka emi ʻana o ka hana hānai a me ka piʻi ʻana o ka naʻau.
ʻO ka hana maʻamau a me ka maikaʻi: ʻAʻole i hoʻopilikia ka maʻi o 10 mg/kg o ka lycorine i nā ʻano maʻamau a me ka maikaʻi o nā ʻiole, e manaʻo ana he hopena maikaʻi loa kēia no nā loiloi therapeutic efficacy e hiki mai ana.
ʻAʻohe hopena koʻikoʻi i ke kaumaha o ke kino a i ʻole ke kūlana olakino: ʻaʻole i hoʻokumu ʻia ka lycorine a me ka lycorine hydrochloride i nā hopena ʻaoʻao i ke kaumaha o ke kino a i ʻole ke kūlana olakino holoʻokoʻa i nā kiʻi ʻiole e lawe ana i ka tumo.
He mea nui e hoʻomaopopo ʻoiai ua hōʻike ʻo lycorine i ka hiki i nā noiʻi preclinical, ʻaʻole naʻe nā loiloi ʻona lōʻihi. Pono ka noiʻi hou aʻe e hoʻomaopopo pono i kona ʻike palekana, ʻoi aku ka nui no ka hoʻohana lōʻihi a ma nā ʻōnaehana lapaʻau. Hiki ke ʻokoʻa nā hopena ʻaoʻao a me ka palekana o ka lycorine ma muli o ke ʻano, ke ʻano o ka lawelawe ʻana, a me nā ʻano maʻi o kēlā me kēia kanaka. E kamaʻilio mau me kahi ʻoihana mālama ola ma mua o ka noʻonoʻo ʻana i ka hoʻohana ʻana i kekahi mea hoʻohui hou a lapaʻau paha.
