Lycorine Hydrochloride
ʻO Lycorine hydrochloride kahi pauka keʻokeʻo a keʻokeʻo paha i loaʻa mai ka alkaloid lycorine, i loaʻa i nā mea kanu o Lycoris radiata (L'Her.), a no ka ʻohana Amaryllidaceae. Loaʻa iā Lycorine hydrochloride nā hopena pharmacological like ʻole, me ka anti-tumor, anti-cancer, anti-HCV, anti-inflammatory, anti-bacterial, anti-virus, anti-angiogenesis, a me nā waiwai anti-malaria. Hiki ke hoʻoheheʻe ʻia i ka wai, DMSO, a me ka ethanol. Hōʻike ʻia kona ʻano kemika e kahi ʻōnaehana steroidal paʻakikī me kahi ʻono ʻawaʻawa me nā hui hana he nui, me nā hui hydroxyl a me amino, e hāʻawi ana i kāna mau hana olaola.
| Inoa huahana | ʻO ka Lycorine hydrochloride CAS: 2188-68-3 | ||
| Puna Mea Kanu | ʻO Lycoris | ||
| Kūlana mālama | E mālama me kahi sila ma ka mahana o ka lumi | Lā hōʻike | 2024.08.24 |
| Mea | Kūlana Maʻamau | Hopena |
| Maʻemaʻe（HPLC） | ʻO Lycorine hydrochloride≥98% | 99.7% |
| helehelena | Pauka keʻokeʻo ʻole | Kūlike |
| ʻAno kinonā ics | ||
| Ka nui o nā ʻāpana | NLT100% 80ʻUpena | Kūlike |
| Pohō ma ka maloʻo ʻana | ≤1.0% | 1.8% |
| Kaumaha metala | ||
| Huina metala | ≤10.0ppm | Kūlike |
| Ke alakaʻi | ≤2.0ppm | Kūlike |
| Mereki | ≤1.0ppm | Kūlike |
| Kadmium | ≤0.5ppm | Kūlike |
| Mea olaola liʻiliʻi | ||
| Ka huina o nā bacteria | ≤1000cfu/g | Kūlike |
| Hū | ≤100cfu/g | Kūlike |
| ʻO ka maʻi Escherichia coli | ʻAʻole i hoʻokomo ʻia | ʻAʻole i ʻike ʻia |
| Salmonella | ʻAʻole i hoʻokomo ʻia | ʻAʻole i ʻike ʻia |
| ʻO ke Staphylococcus | ʻAʻole i hoʻokomo ʻia | ʻAʻole i ʻike ʻia |
| Nā hopena | Kūpono | |
Nā Hiʻohiʻona:
(1) Maʻemaʻe Kiʻekiʻe:Ua hana pono ʻia kā mākou huahana e hōʻoia i kahi kiʻekiʻe o ka maʻemaʻe, he mea nui ia no kona pono a me ka palekana i nā hana like ʻole.
(2) Nā Waiwai Kū'ē i ka Maʻi ʻAʻai:Ua hōʻike ʻia nā hopena anticancer koʻikoʻi e kūʻē i nā ʻano maʻi kanesa like ʻole, ʻo in vitro a me in vivo, ma o nā hana e like me ke koi ʻana i ka hopu ʻana o ke kaʻina hana cell, hoʻoulu i ka apoptosis, a me ka pale ʻana i ka angiogenesis.
(3) Hana i hoʻolālā nui ʻia:Ua manaʻoʻiʻo ʻia ʻo Lycorine hydrochloride e launa pū me nā pahuhopu molekala he nui, e hāʻawi ana i kahi hopena ākea ākea e kūʻē i nā hunaola kanesa.
(4) Haʻahaʻa ka ʻawahia:Hōʻike ia i ka haʻahaʻa o ka ʻawahia i nā pūnaewele maʻamau, he mea nui ia i kona hiki ke hoʻohana ʻia ma ke ʻano he mea hoʻōla.
(5) ʻIkepili Pharmacokinetic:Ua aʻo ʻia ka huahana no kona pharmacokinetics, e hōʻike ana i ka absorption wikiwiki a me ka hoʻopau wikiwiki ʻana mai ka plasma, he mea nui ia no ka dosing a me ka hoʻolālā therapy.
(6) Nā hopena Synergistic:Ua hōʻike ʻo Lycorine hydrochloride i nā hopena i hoʻonui ʻia i ka wā e hoʻohana ʻia ai me nā lāʻau ʻē aʻe, kahi mea e pono ai ke lanakila i ke kūʻē ʻana i ka lāʻau a me ka hoʻomaikaʻi ʻana i nā hopena lapaʻau.
(7) Kākoʻo ʻia e ka noiʻi:Kākoʻo ʻia ka huahana e ka noiʻi nui, e hāʻawi ana i kahi kahua paʻa no kona hoʻohana ʻana i ka hoʻomohala lāʻau lapaʻau a me nā noi lapaʻau.
(8) Hōʻoiaʻiʻo Kūlana:Ua hoʻokō ʻia nā hana kaohi maikaʻi koʻikoʻi ma ke kaʻina hana holoʻokoʻa e hōʻoia i ke kūlike a me ka hilinaʻi o ka huahana.
(9) Nā Hoʻohana Kūikawā:Kūpono no ka hoʻohana ʻana i ka noiʻi a me ka hoʻomohala ʻana no nā noi lāʻau lapaʻau, me ka ʻike ʻana i nā lāʻau lapaʻau a me ka hoʻomohala ʻana i ka lāʻau lapaʻau.
(10) Hoʻokō:Hana ʻia e like me nā kūlana GMP e hōʻoia i ka palekana a me ka pono o ka huahana.
(1) ʻOihana lāʻau lapaʻau:Hoʻohana ʻia ʻo Lycorine hydrochloride i ka hoʻomohala ʻana i nā lāʻau antiviral a me nā lāʻau anticancer.
(2) ʻOihana ʻenehana biotechnology:Hoʻohana ʻia ia i ka noiʻi a me ka hoʻomohala ʻana i nā mea lapaʻau hou a me nā ʻano lāʻau lapaʻau.
(3) Noiʻi huahana kūlohelohe:Ua aʻo ʻia ʻo Lycorine hydrochloride no kona mau pono olakino a me nā waiwai lapaʻau.
(4) ʻOihana kemika:Hiki ke hoʻohana ʻia ma ke ʻano he kemika waena i ka synthesis o nā hui ʻē aʻe.
(5) ʻOihana mahiʻai:Ua noiʻi ʻia ʻo Lycorine hydrochloride no kona hiki ke lilo i mea pesticide kūlohelohe a me ka mea hoʻoponopono ulu mea kanu.
ʻO ke kaʻina hana unuhi o ka lycorine hydrochloride e komo pū me kēia mau ʻanuʻu koʻikoʻi e hōʻoia i ka maʻemaʻe o ka mea hoʻoheheʻe a hoʻomaikaʻi i ka wikiwiki o ka hoʻōla ʻana:
(1) Ke koho ʻana i nā mea maka a me ka mālama mua ʻana:E koho i nā mea kanu Amaryllidaceae kūpono, e like me nā ʻuala Amaryllis, a holoi, hoʻomaloʻo a kuʻi iā lākou e hōʻoia i ka maʻemaʻe o nā mea maka a waiho i ke kahua no ka unuhi ʻana ma hope.
(2)Ka mālama mua ʻana o ka enzyme composite:E hoʻohana i nā enzymes paʻakikī (e like me cellulase a me pectinase) e mālama mua i nā mea maka i kuʻi ʻia e hoʻopau i nā paia o nā cell mea kanu a hoʻomaikaʻi i ka pono o ka unuhi ʻana ma hope.
(3)Hoʻoheheʻe ʻia ka waikawa hydrochloric:E kāwili i nā mea maka i mālama mua ʻia me ka hopena waikawa hydrochloric dilute e unuhi i ka lycorine. ʻO ka hoʻohana ʻana i ka waikawa hydrochloric e kōkua i ka hoʻonui ʻana i ka solubility o ka lycorine, a laila e hoʻomaikaʻi ai i ka pono o ka unuhi ʻana.
(4)Ka unuhi ʻana me ke kōkua o ka Ultrasonic:ʻE lava ke faʻavavevave ʻia ke kaʻina hana hoʻoheheʻe ʻana o ka lycorine i loko o ka mea hoʻoheheʻe ʻia e ka hoʻohana ʻana i ka ʻenehana unuhi ultrasonic i ke kaʻina hana hoʻoheheʻe ʻana a hoʻomaikaʻi i ka pono a me ka maʻemaʻe o ka unuhi ʻana.
(5)Ka unuhi ʻana o ke kloroform:Hana ʻia ka unuhi ʻana me nā mea hoʻoheheʻe organik e like me chloroform, a hoʻoili ʻia ka lycorine mai ka pae wai i ka pae organik e hoʻomaʻemaʻe hou aku i ka hui i manaʻo ʻia.
(6)Hoʻōla hou ʻana o ka mea hoʻoheheʻe:Ma hope o ke kaʻina hana unuhi, hoʻihoʻi ʻia ka solvent ma o ka hoʻoheheʻe ʻana a i ʻole ka distillation e hōʻemi i ka hoʻohana ʻana i ka solvent a hoʻomaikaʻi i ka hoʻokele waiwai.
(7)Hoʻomaʻemaʻe a me ka hoʻomaloʻo ʻana:Ma o nā ʻanuʻu hoʻomaʻemaʻe a me ka maloʻo kūpono, loaʻa ka pauka lycorine hydrochloride maʻemaʻe.
Ma ke kaʻina hana hoʻokaʻawale holoʻokoʻa, ʻo ke kāohi ʻana i ke koho ʻana o ka solvent, nā kūlana hoʻokaʻawale (e like me ka waiwai pH, ka mahana, a me ka manawa), a me nā ʻanuʻu hoʻomaʻemaʻe ma hope iho ke kī i ka hōʻoia ʻana i ka maʻemaʻe o ka solvent a me ka hoʻomaikaʻi ʻana i ka wikiwiki o ka hoʻōla ʻana. ʻO ka hoʻohana ʻana i nā lako hoʻokaʻawale a me ka hoʻomaʻemaʻe hou, e like me nā mea hoʻokaʻawale ultrasonic a me nā ʻōnaehana chromatography wai hana kiʻekiʻe (HPLC), kōkua pū i ka hoʻomaikaʻi ʻana i ka pono o ka hoʻokaʻawale ʻana a me ka maikaʻi o ka huahana.
Mālama ʻana: E mālama i kahi wahi anu, maloʻo, a maʻemaʻe, mai ka makū a me ka mālamalama pololei.
Pūʻolo nui: 25kg/pahu.
Ka Manawa Alakaʻi: 7 mau lā ma hope o kāu kauoha.
Ola papa: 2 mau makahiki.
Manaʻo: Hiki ke hoʻokō ʻia nā kikoʻī i hoʻopilikino ʻia.
Hoʻolaha wikiwiki
Ma lalo o 100kg, 3-5 mau lā
Maikaʻi ka lawe ʻana i nā waiwai mai kēlā puka a i kēia puka
Ma ke Kai
Ma luna o 300kg, Ma kahi o 30 mau lā
Pono ka ʻelele hoʻokuʻu loea o ka lawelawe awa a i awa
Ma ka mokulele
100kg-1000kg, 5-7Lā
Pono ka ʻelele hoʻomaʻemaʻe loea lawelawe mokulele i ke kahua mokulele
Ua loaʻa iā Bioway Organic nā palapala hōʻoia USDA a me EU organic, BRC, ISO, HALAL, KOSHER, a me HACCP.
He alkaloid kūlohelohe ʻo Lycorine i loaʻa i loko o kekahi mau mea kanu, ʻoi aku hoʻi i loko o ka ʻohana Amaryllidaceae. Eia kekahi mau mea kanu i ʻike ʻia he lycorine:
ʻO Lycoris radiataʻO ka līlia punawelewele ʻulaʻula (i ʻike ʻia hoʻi ʻo ka līlia nananana ʻulaʻula a i ʻole ka manjushage) he lāʻau lapaʻau kuʻuna Kina nona ka lycorine.
Leucojum aestivum(ka hau hau kauwela), ua ʻike ʻia hoʻi he lycorine.
ʻUngernia sewertzowiiʻO ia kekahi mea kanu mai ka ʻohana Amaryllidaceae i hōʻike ʻia he lycorine kona.
ʻO ka Hippeastrum hybrid (ka līlia Easter)a me nā mea kanu ʻē aʻe e pili ana iā Amaryllidaceae he mau kumu i ʻike ʻia o ka lycorine.
Ua laha nui kēia mau mea kanu ma nā wahi wela a me nā wahi subtropical a puni ka honua a he mōʻaukala lōʻihi ko lākou o ka hoʻohana ʻana i ka lāʻau lapaʻau kuʻuna. ʻO ke alo o ka lycorine i loko o kēia mau mea kanu ke kumuhana o ka noiʻi ma muli o kona mau waiwai pharmacological hiki, me kona mau hopena anticancer koʻikoʻi e like me ka mea i hōʻike ʻia ma nā haʻawina like ʻole.
He alkaloid kūlohelohe ʻo Lycorine me nā hopena pharmacological like ʻole, me kona hiki ke hoʻohana ʻia i ka mālama ʻana i ka maʻi kanesa. ʻOiai ua hōʻike ʻo ia i nā hopena hoʻohiki i nā haʻawina like ʻole, aia kekahi mau hopena ʻaoʻao i hōʻike ʻia a me nā manaʻo e pili ana i kona hoʻohana ʻana:
ʻAʻohe ʻawahia: Hōʻike pinepine ʻo Lycorine a me kona paʻakai hydrochloride i ka ʻawahia haʻahaʻa, he ʻano maikaʻi ia no nā noi lapaʻau. Ua hōʻike ʻia he liʻiliʻi nā hopena maikaʻi ʻole ma nā pūnaewele kanaka maʻamau a me nā ʻiole olakino, e hōʻike ana i kahi pae koho no nā pūnaewele maʻi ʻaʻai ma mua o nā ʻiʻo maʻamau.
Nā Hopena ʻEmetic Kuikilana: Ua ʻike ʻia ka nausea a me ka luaʻi pōkole ma hope o ka hoʻokomo ʻia ʻana o ka lycorine hydrochloride ma lalo o ke kino a i ʻole ma loko o ka ʻōpū, e emi pinepine ana i loko o 2.5 mau hola me ka ʻole o ka hoʻopilikia ʻana i ka palekana biochemical a i ʻole hematological.
ʻAʻohe Hoʻonohonoho Motika i Hoʻopilikia ʻia: Ua hōʻike ʻia nā noiʻi ʻaʻole hoʻopilikia nā mahele serial o lycorine i ka hoʻonohonoho motika i nā ʻiole, e like me ka hoʻāʻo ʻia e ka hoʻāʻo rotarod, e hōʻike ana ʻaʻole ia e alakaʻi i nā hopena ʻaoʻao o ka ʻōnaehana nerve waena (CNS) e pili ana i ka kaohi motika.
Hopena ma ka Hana Locomotor Kūlohelohe: Ma kahi mahele o 30 mg/kg, ua ʻike ʻia ka lycorine e hoʻopilikia i ka hana locomotor kūlohelohe i nā ʻiole, e like me ka mea i hōʻike ʻia e ka emi ʻana o ke ʻano hānai a me ka piʻi ʻana o ka paʻa ʻole.
ʻAno Laulā a me ke Ola Kino: ʻAʻole i hoʻopilikia ka mahele o 10 mg/kg o lycorine i nā ʻano laulā a me ke olakino o nā ʻiole, e hōʻike ana he mahele kūpono paha kēia no nā loiloi pono lapaʻau i ka wā e hiki mai ana.
ʻAʻohe hopena koʻikoʻi ma ke kaumaha o ke kino a i ʻole ke kūlana olakino: ʻAʻole i loaʻa nā hopena ʻaoʻao koʻikoʻi i ka hoʻokele ʻana o ka lycorine a me ka lycorine hydrochloride i ke kaumaha o ke kino a i ʻole ke kūlana olakino holoʻokoʻa i nā hiʻohiʻona ʻiole me ka puʻupuʻu.
He mea nui e hoʻomaopopo ʻoiai ua hōʻike ʻia ka lycorine i ka hiki ke hana i nā noiʻi preclinical, ʻaʻole i lawa nā loiloi ʻawahia lōʻihi. Pono ka noiʻi hou aku e hoʻomaopopo piha i kona ʻano palekana, ʻoiai no ka hoʻohana lōʻihi a ma nā wahi lapaʻau. Hiki ke ʻokoʻa nā hopena ʻaoʻao a me ka palekana o ka lycorine ma muli o ka nui o ka lāʻau, ke ʻano o ka lawelawe ʻana, a me nā ʻano o kēlā me kēia maʻi. E kūkākūkā mau me kahi loea mālama ola ma mua o ka noʻonoʻo ʻana i ka hoʻohana ʻana i kekahi mea hoʻohui a lāʻau lapaʻau hou.
